Deferipron

Deferipron
Klinički podaci
Drugs.comMonografija
Način primeneOralno
Identifikatori
CAS broj30652-11-0 Зелена квачицаДа
ATC kodV03AC02 (WHO)
PubChemCID 2972
DrugBankDB08826 Зелена квачицаДа
ChemSpider2866 Зелена квачицаДа
ChEBICHEBI:68554 Зелена квачицаДа
ChEMBLCHEMBL70927 Зелена квачицаДа

Deferipron je organsko jedinjenje, koje sadrži 7 atoma ugljenika i ima molekulsku masu od 139,152 Da.[1][2][3][4]

Osobine

Osobina Vrednost
Broj akceptora vodonika 3
Broj donora vodonika 1
Broj rotacionih veza 0
Particioni koeficijent[5] (ALogP) -0,1
Rastvorljivost[6] (logS, log(mol/L)) -0,4
Polarna površina[7] (PSA, Å2) 40,5

Reference

  1. ^ Roberts DJ, Brunskill SJ, Doree C, Williams S, Howard J, Hyde CJ: Oral deferiprone for iron chelation in people with thalassaemia. Cochrane Database Syst Rev. 2007 Jul 18;(3):CD004839. Roberts, D. J.; Brunskill, S. J.; Doree, C.; Williams, S.; Howard, J.; Hyde, C. J. (2007). Roberts, David, ур. „Oral deferiprone for iron chelation in people with thalassaemia”. The Cochrane Database of Systematic Reviews (3): CD004839. PMID 17636775. doi:10.1002/14651858.CD004839.pub2. 
  2. ^ Victor Hoffbrand A: Deferiprone therapy for transfusional iron overload. Victor Hoffbrand, A. (јун 2005). „Deferiprone therapy for transfusional iron overload”. Best Pract Res Clin Haematol. 18 (2): 299—317. PMID 15737892. doi:10.1016/j.beha.2004.08.026. 
  3. ^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 Слободан приступ. PMID 21059682. doi:10.1093/nar/gkq1126. 
  4. ^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 Слободан приступ. PMID 18048412. doi:10.1093/nar/gkm958. 
  5. ^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o. 
  6. ^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  7. ^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura

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