Defibrotid

Defibrotid
Klinički podaci
Prodajno imeDasovas, Noravid, Prociclide
Drugs.comMonografija
Način primeneIntramaskularno, oralno
Identifikatori
CAS broj83712-60-1 Зелена квачицаДа
ATC kodB01AX01 (WHO)
DrugBankDB04932 Зелена квачицаДа

Defibrotid je natrimova so smeše jednolančanih oligodezoksiribonukleotida izvedenih iz DNK svinjske sluzokože ili goveđih pluća. Defibrotid ima antitrombotska, antiinflamatorna i antiishemijska svojstva (bez znatnih sistemskih antikoagulantskih efekata). On je u prodaji pod imenima: Dasovas (FM), Noravid, i Prociclide.[1][2][3][4][5][6][7][8]

Reference

  1. ^ Noseda, G.; Fragiacomo, C.; Ferrari, D. (1986). „Pharmacokinetics of defibrotide in healthy volunteers”. Haemostasis. 16 Suppl 1: 26—30. PMID 3754833. doi:10.1159/000215336. }-
  2. ^ Palmer, K. J.; Goa, K. L. (фебруар 1993). „Defibrotide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in vascular disorders”. Drugs. 45 (2): 259—94. PMID 7681375. doi:10.2165/00003495-199345020-00007. }-
  3. ^ Fisher J; Johnston AM; Holland TK; McCallum J; Pescador R; Mantovani M, Prino G (април 1993). „Pharmacokinetics, absorption, distribution and disposition of [125I]-defibrotide following intravenous or oral administration in the rat”. Thromb Res. 70 (1): 77—90. PMID 8511753. doi:10.1016/0049-3848(93)90225-d. 
  4. ^ Koehl GE, Geissler EK, Iacobelli M, Frei C, Burger V, Haffner S, Holler E, Andreesen R, Schlitt HJ, Eissner G: Defibrotide: An Endothelium Protecting and Stabilizing Drug, has an Anti-Angiogenic Potential In Vitro and In Vivo. Cancer Biol Ther. 2007 May;Koehl, G. E.; Geissler, E. K.; Iacobelli, M.; Frei, C.; Burger, V.; Haffner, S.; Holler, E.; Andreesen, R.; Schlitt, H. J.; Eissner, G. (2007). „Defibrotide: An endothelium protecting and stabilizing drug, has an anti-angiogenic potential in vitro and in vivo”. Cancer Biology & Therapy. 6 (5): 686—90. PMID 17495522. doi:10.4161/cbt.6.5.3959. . Epub 2007 Feb 3.
  5. ^ Kornblum, N.; Ayyanar, K.; Benimetskaya, L.; Richardson, P.; Iacobelli, M.; Stein, C. A. (2006 Spring). „Defibrotide, a polydisperse mixture of single-stranded phosphodiester oligonucleotides with lifesaving activity in severe hepatic veno-occlusive disease: Clinical outcomes and potential mechanisms of action”. Oligonucleotides. 16 (1): 105—14. PMID 16584299. doi:10.1089/oli.2006.16.105.  Проверите вредност парамет(а)ра за датум: |date= (помоћ)}-
  6. ^ Pescador, R.; Porta, R.; Ferro, L. (1996). „An integrated view of the activities of defibrotide”. Seminars in Thrombosis and Hemostasis. 22 Suppl 1: 71—75. PMID 8807733. }-
  7. ^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 Слободан приступ. PMID 21059682. doi:10.1093/nar/gkq1126. 
  8. ^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 Слободан приступ. PMID 18048412. doi:10.1093/nar/gkm958. 

Literatura

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