Enoksimon

Enoksimon
Klinički podaci
Drugs.comMonografija
Način primeneOralno
Identifikatori
CAS broj77671-31-9 Зелена квачицаДа
ATC kodC01CE03 (WHO)
PubChemCID 53708
DrugBankDB04880 Зелена квачицаДа
ChemSpider48492 Зелена квачицаДа
ChEMBLCHEMBL249856 Зелена квачицаДа

Enoksimon je organsko jedinjenje, koje sadrži 12 atoma ugljenika i ima molekulsku masu od 248,301 Da.[1][2][3][4][5][6]

Osobine

Osobina Vrednost
Broj akceptora vodonika 3
Broj donora vodonika 2
Broj rotacionih veza 3
Particioni koeficijent[7] (ALogP) 1,3
Rastvorljivost[8] (logS, log(mol/L)) -3,0
Polarna površina[9] (PSA, Å2) 83,5

Reference

  1. ^ Sandroni C, Cavallaro F, Caricato A, Scapigliati A, Fenici P, Antonelli M: Enoximone in cardiac arrest caused by propranolol: two case reports. Sandroni, C.; Cavallaro, F.; Caricato, A.; Scapigliati, A.; Fenici, P.; Antonelli, M. (2006 Jul). „Enoximone in cardiac arrest caused by propranolol: Two case reports”. Acta Anaesthesiol Scand. 50 (6): 759—61. PMID 16987374. doi:10.1111/j.1399-6576.2006.01026.x.  Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  2. ^ van der Maaten JM, de Vries AJ, Rietman GW, Gallandat Huet RC, De Hert SG: Effects of preemptive enoximone on left ventricular diastolic function after valve replacement for aortic stenosis. J Cardiothorac Vasc Anesth. Van Der Maaten, J. M.; De Vries, A. J.; Rietman, G. W.; Gallandat Huet, R. C.; De Hert, S. G. (2007 Jun). „Effects of preemptive enoximone on left ventricular diastolic function after valve replacement for aortic stenosis”. Journal of Cardiothoracic and Vascular Anesthesia. 21 (3): 357—66. PMID 17544886. doi:10.1053/j.jvca.2006.01.006.  Проверите вредност парамет(а)ра за датум: |date= (помоћ). Epub 2006 May 4.
  3. ^ Schauvliege S, Van den Eede A, Duchateau L, Gasthuys F: Cardiovascular effects of enoximone in isoflurane anaesthetized ponies. Vet Anaesth Analg. 2007 Aug 13;. Schauvliege, S.; Van Den Eede, A.; Duchateau, L.; Gasthuys, F. (2007). „Cardiovascular effects of enoximone in isoflurane anaesthetized ponies”. Veterinary Anaesthesia and Analgesia. 34 (6): 416—430. PMID 17696974. doi:10.1111/j.1467-2995.2007.00343.x. 
  4. ^ Boldt J, Suttner S: Combined use of ultra-short acting beta-blocker esmolol and intravenous phosphodiesterase 3 inhibitor enoximone. Boldt, J.; Suttner, S. (2007 Sep). „Combined use of ultra-short acting beta-blocker esmolol and intravenous phosphodiesterase 3 inhibitor enoximone”. Expert Opin Pharmacother. 8 (13): 2135—47. PMID 17714066. doi:10.1517/14656566.8.13.2135.  Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  5. ^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 Слободан приступ. PMID 21059682. doi:10.1093/nar/gkq1126. 
  6. ^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 Слободан приступ. PMID 18048412. doi:10.1093/nar/gkm958. 
  7. ^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o. 
  8. ^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  9. ^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura

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