Estron

Estron
Klinički podaci
Prodajno imeAquacrine, Crinovaryl, Cristallovar, Crystogen
Drugs.comMonografija
Način primeneIntravaginalno, oralno
Identifikatori
CAS broj53-16-7 Зелена квачицаДа
ATC kodG03CA07 (WHO), G03CC04
PubChemCID 5870
IUPHAR/BPS2818
DrugBankDB00655 Зелена квачицаДа
ChemSpider5660 Зелена квачицаДа
KEGGC00468 Зелена квачицаДа
ChEBICHEBI:17263 Зелена квачицаДа
ChEMBLCHEMBL1405 Зелена квачицаДа

Estron je organsko jedinjenje, koje sadrži 18 atoma ugljenika i ima molekulsku masu od 270,366 Da.[1][2][3][4]

Osobine

Osobina Vrednost
Broj akceptora vodonika 2
Broj donora vodonika 1
Broj rotacionih veza 0
Particioni koeficijent[5] (ALogP) 3,9
Rastvorljivost[6] (logS, log(mol/L)) -4,5
Polarna površina[7] (PSA, Å2) 37,3

Reference

  1. ^ Miyoshi Y, Tanji Y, Taguchi T, Tamaki Y, Noguchi S. Miyoshi, Y.; Tanji, Y.; Taguchi, T.; Tamaki, Y.; Noguchi, S. (2003 Jun). „Association of serum estrone levels with estrogen receptor-positive breast cancer risk in postmenopausal Japanese women”. Clin Cancer Res. 9 (6): 2229—33. PMID 12796390.  Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  2. ^ Kajta M, Lason W, Bien E, Marszal M: Neuroprotective effects of estrone on NMDA-induced toxicity in primary cultures of rat cortical neurons are independent of estrogen receptors. Pol J Pharmacol. 2002 Nov-Dec;Kajta, M.; Lasoń, W.; Bień, E.; Marszał, M. (2002). „Neuroprotective effects of estrone on NMDA-induced toxicity in primary cultures of rat cortical neurons are independent of estrogen receptors”. Polish Journal of Pharmacology. 54 (6): 727—9. PMID 12866733. 
  3. ^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 Слободан приступ. PMID 21059682. doi:10.1093/nar/gkq1126. 
  4. ^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 Слободан приступ. PMID 18048412. doi:10.1093/nar/gkm958. 
  5. ^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o. 
  6. ^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  7. ^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura

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