Foledrin

Foledrin
Klinički podaci
Drugs.comMonografija
Identifikatori
CAS broj370-14-9 Зелена квачицаДа
ATC kodNone
PubChemCID 4655
ChemSpider4494 Зелена квачицаДа
UNIIAY28O44JGD Зелена квачицаДа
KEGGD08370 Зелена квачицаДа

Foledrin (Paredrinol, Pulsotil, Veritol), takođe poznat kao 4-hidroksi-N-metilamfetamin (4-HMA), 4-hidroksimetamfetamin, i para-hidroksimetamfetamin,[1] lek je koji stimuliše simpatički nervni sistem.[2] On se topikalno administrira u obliku kapima za oči radi širenja zenica i može se koristiti za uspostavljanje dijagnoze Hornerovog sindroma.[2]

Metabolički putevi metamfetamina
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Foledrin je jedan od metamfetaminska dva neposredna metabolita kod ljudi.

Osobine

Foledrin je organsko jedinjenje, koje sadrži 10 atoma ugljenika i ima molekulsku masu od 165,232 Da.

Osobina Vrednost
Broj akceptora vodonika 2
Broj donora vodonika 2
Broj rotacionih veza 3
Particioni koeficijent[3] (ALogP) 1,8
Rastvorljivost[4] (logS, log(mol/L)) -2,3
Polarna površina[5] (PSA, Å2) 32,3

Reference

  1. ^ P-HYDROXYMETHAMPHETAMINE CAS#: 370-14-9
  2. ^ а б Bates, A. T.; Chamberlain, S.; Champion, M.; Foley, L.; Hughes, E.; Jani, B.; Mehta, H.; Smith, S. E. (1995). „Pholedrine: A substitute for hydroxyamphetamine as a diagnostic eyedrop test in Horner's syndrome”. Journal of neurology, neurosurgery, and psychiatry. 58 (2): 215—217. PMC 1073320 Слободан приступ. PMID 7876854. doi:10.1136/jnnp.58.2.215. 
  3. ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 
  4. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci.. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  5. ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem.. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura

Spoljašnje veze

Foledrin на Викимедијиној остави.

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