Gabapentin

Gabapentin
Klinički podaci
Prodajno imeAclonium, Neurontin, Novo-Gabapentin
Drugs.comMonografija
Način primeneOralno
Identifikatori
CAS broj60142-96-3 Зелена квачицаДа
ATC kodN03AX12 (WHO)
PubChemCID 3446
DrugBankDB00996 Зелена квачицаДа
ChemSpider3328 Зелена квачицаДа
ChEMBLCHEMBL940 Зелена квачицаДа

Gabapentin je organsko jedinjenje, koje sadrži 9 atoma ugljenika i ima molekulsku masu od 171,237 Da.[1][2][3][4][5][6][7][8][9]

Osobine

Osobina Vrednost
Broj akceptora vodonika 3
Broj donora vodonika 2
Broj rotacionih veza 3
Particioni koeficijent[10] (ALogP) -1,5
Rastvorljivost[11] (logS, log(mol/L)) -2,0
Polarna površina[12] (PSA, Å2) 63,3

Reference

  1. ^ Mathew, N. T.; Rapoport, A.; Saper, J.; Magnus, L.; Klapper, J.; Ramadan, N.; Stacey, B.; Tepper, S. (фебруар 2001). „Efficacy of gabapentin in migraine prophylaxis”. Headache.. 41 (2): 119—28. PMID 11251695. doi:10.1046/j.1526-4610.2001.111006119.x. 
  2. ^ Backonja, M. M.; Serra, J. (2004). „Pharmacologic management part 1: Better-studied neuropathic pain diseases”. Pain Medicine (Malden, Mass.). 5 Suppl 1: S28—47. PMID 14996228. doi:10.1111/j.1526-4637.2004.04020.x. 
  3. ^ Choudhuri, I.; Sarvananthan, N.; Gottlob, I. (септембар 2007). „Survey of management of acquired nystagmus in the United Kingdom”. Eye. 21 (9): 1194—7. PMID 16732211. doi:10.1038/sj.eye.6702434. 
  4. ^ Pande, A. C.; Crockatt, J. G.; Janney, C. A.; Werth, J. L.; Tsaroucha, G. (2000). „Gabapentin in bipolar disorder: A placebo-controlled trial of adjunctive therapy. Gabapentin Bipolar Disorder Study Group”. Bipolar Disorders. 2 (3 Pt 2): 249—255. PMID 11249802. doi:10.1034/j.1399-5618.2000.20305.x. 
  5. ^ Su, T. Z.; Feng, M. R.; Weber ML. (јун 2005). „Mediation of highly concentrative uptake of pregabalin by L-type amino acid transport in Chinese hamster ovary and Caco-2 cells.”. J Pharmacol Exp Ther.. 313 (3): 1406—15. PMID 15769862. doi:10.1124/jpet.104.082255. . Epub 2005 Mar 15. .
  6. ^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 Слободан приступ. PMID 21059682. doi:10.1093/nar/gkq1126. 
  7. ^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 Слободан приступ. PMID 18048412. doi:10.1093/nar/gkm958. 
  8. ^ Khademi S, Ghaffarpasand F, Heiran HR, Asefi A (2010). „Effects of preoperative gabapentin on postoperative nausea and vomiting after open cholecystectomy: A prospective randomized double-blind placebo-controlled study”. Med Princ Pract. 19 (1): 57—60. PMID 19996621. doi:10.1159/000252836. 
  9. ^ Bashir F, Bhat KM, Qazi S, Hashia AM (2009). „A randomized, double blind, placebo controlled study evaluating preventive role of gabapentin for PONV in patients undergoing laparascopic cholecystectomy”. JK Sci. 11: 190—3. 
  10. ^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o. 
  11. ^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  12. ^ Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura

Spoljašnje veze

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.