Keksin

Keksin
Identifikatori
EC broj3.4.21.61
CAS broj99676-46-7
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Keksin (EC 3.4.21.61, proteinaza yscF, prohormon-transformišuća endoproteaza, uparena-bazna endopeptidaza, kvaščana cisteinska proteinaza F, uparena-bazna endopeptidaza, andrenorfin-Gly-generišući enzim, endoproteinaza Kex2p, gen KEX2 dibazna proteinaza, Kex 2p proteinaza, Kex2 endopeptidaza, Kex2 endoproteaza, Kex2 endoproteinaza, Kex2 proteaza, proteinaza Kex2p, proteinaza transformacije prohormona, proproteinska konvertaza, proteaza KEX2, Kex2 proteinaza, Kex2-slična endoproteinaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Razlaganje -Lys-Arg- i -Arg-Arg- veza u kvaščanom alfa-faktorskom feromonu i prekurzorima smrtonisnih toksina

Ova peptidaza se aktivira jonom Ca2+.

Reference

  1. ^ Julius, D., Brake, A., Blair, L., Kunisawa, R. and Thorner, J. (1984). „Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor”. Cell. 37: 1075—1089. PMID 6430565. 
  2. ^ Achstetter, T. & Wolf, D.H. (1985). „Hormone processing and membrane-bound proteinases in yeast”. EMBO J.. 4: 173—177. PMID 3894003. 
  3. ^ Mizuno, K., Nakamura, T., Ohshima, T., Tanaka, S. and Matsuo, H. (1988). „Yeast KEX2 gene encodes an endopeptidase homologous to subtilisin-like serine proteases”. Biochem. Biophys. Res. Commun.. 156: 246—254. PMID 2845974. 
  4. ^ Fuller, R.S., Brake, A. and Thorner, J. (1989). „Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease”. Proc. Natl. Acad. Sci. USA. 86: 1434—1438. PMID 2646633. 
  5. ^ Mizuno, K., Nakamura, T., Ohshima, T., Tanaka, S. and Matsuo, H. (1989). „Characterization of KEX2-encoded endopeptidase from yeast Saccharomyces cerevisiae”. Biochem. Biophys. Res. Commun.. 159: 305—311. PMID 2845974. 

Literatura

Spoljašnje veze

  • Kexin на US National Library of Medicine Medical Subject Headings (MeSH)

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