Metrizamid

Metrizamid
Klinički podaci
Drugs.comMonografija
Identifikatori
CAS broj31112-62-6 Зелена квачицаДа
ATC kodV08AB01 (WHO)
PubChemCID 443944
DrugBankDB01578 Зелена квачицаДа
ChemSpider391998 Зелена квачицаДа
ChEMBLCHEMBL1200889 Зелена квачицаДа

Metrizamid je organsko jedinjenje, koje sadrži 18 atoma ugljenika i ima molekulsku masu od 789,096 Da.[1][2][3][4]

Osobine

Osobina Vrednost
Broj akceptora vodonika 8
Broj donora vodonika 6
Broj rotacionih veza 5
Particioni koeficijent[5] (ALogP) -0,9
Rastvorljivost[6] (logS, log(mol/L)) -5,4
Polarna površina[7] (PSA, Å2) 168,7

Reference

  1. ^ Azuma, H.; Nomura, S.; Ikoma, Y.; Yokoyama, M.; Oshino, N. (1989). „A possible mechanism for the neural adverse reactions caused by metrizamide”. Fortschritte Auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband. 128: 134—42. PMID 2568781. 
  2. ^ Ekholm, S. E.; Reece, K.; Coleman, J. R.; Kido, D. K.; Fischer, H. W. (април 1983). „Metrizamide--a potential in vivo inhibitor of glucose metabolism”. Radiology. 147 (1): 119—21. PMID 6828715. doi:10.1148/radiology.147.1.6828715. 
  3. ^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 Слободан приступ. PMID 21059682. doi:10.1093/nar/gkq1126. 
  4. ^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 Слободан приступ. PMID 18048412. doi:10.1093/nar/gkm958. 
  5. ^ . doi:10.1021/jp980230o.  Недостаје или је празан параметар |title= (помоћ)
  6. ^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  7. ^ Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura

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