Organoid
Organoid je minijaturizovana i pojednostavljena verzija organa proizvedenog in vitro u tri dimenzije koja imitira ključnu funkcionalnu, strukturnu i biološku složenost tog organa.[1] Izvodi se iz jedne ili nekoliko ćelija iz tkiva, embrionalnih matičnih ćelija ili indukovanih pluripotentnih matičnih ćelija, koje se mogu samoorganizovati u trodimenzionalnoj kulturi zahvaljujući svojim sposobnostima samoobnavljanja i diferencijacije. Tehnika uzgoja organoida se brzo poboljšala od ranih 2010-ih, a The Scientist ju je nazvao jednim od najvećih naučnih dostignuća 2013. godine.[2] Naučnici i inženjeri koriste organoide za proučavanje razvoja i bolesti u laboratoriji, za otkrivanje i razvoj lekova u industriji,[3] personalizovanu dijagnostiku i medicinu, genske i ćelijske terapije, inženjering tkiva i regenerativnu medicinu.
Reference
- ^ Zhao Z, Chen X, Dowbaj AM, Sljukic A, Bratlie K, Lin L, Fong EL, Balachander GM, Chen Z, Soragni A, Huch M, Zeng YA, Wang Q, Yu H (2022). „Organoids”. Nature Reviews. Methods Primers. 2. PMC 10270325
. PMID 37325195. doi:10.1038/s43586-022-00174-y.
- ^ Grens K (24. 12. 2013). „2013's Big Advances in Science”. The Scientist. Приступљено 26. 12. 2013.
- ^ Mullard A (март 2023). „Mini-organs attract big pharma”. Nature Reviews. Drug Discovery. 22 (3): 175—176. PMID 36797431. doi:10.1038/d41573-023-00030-y.
Literatura
- Chi KR (септембар 2015). „Orchestrating Organoids. A guide to crafting tissues in a dish that reprise in vivo organs”. The Scientist.
- Takebe T, Enomura M, Yoshizawa E, Kimura M, Koike H, Ueno Y, Matsuzaki T, Yamazaki T, Toyohara T, Osafune K, Nakauchi H, Yoshikawa HY, Taniguchi H (мај 2015). „Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell-Driven Condensation”. Cell Stem Cell. 16 (5): 556—565. PMID 25891906. doi:10.1016/j.stem.2015.03.004 .
- Turner DA, Baillie-Johnson P, Martinez Arias A (фебруар 2016). „Organoids and the genetically encoded self-assembly of embryonic stem cells”. BioEssays. 38 (2): 181—191. PMC 4737349 . PMID 26666846. doi:10.1002/bies.201500111.
- Willyard C (јул 2015). „The boom in mini stomachs, brains, breasts, kidneys and more”. Nature. 523 (7562): 520—522. Bibcode:2015Natur.523..520W. PMID 26223610. doi:10.1038/523520a .
Spoljašnje veze
- „Organoid-based regenerative medicine”. Longevity Wiki. 30. 3. 2024.
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