Orlistat

Orlistat
Klinički podaci
Prodajno imeAlli, Xenical
Drugs.comMonografija
Način primeneOralno
Identifikatori
CAS broj96829-58-2 Зелена квачицаДа
ATC kodA08AB01 (WHO)
PubChemCID 3034010
DrugBankDB01083 Зелена квачицаДа
ChemSpider2298564 Зелена квачицаДа
ChEMBLCHEMBL175247 Зелена квачицаДа

Orlistat je organsko jedinjenje, koje sadrži 29 atoma ugljenika i ima molekulsku masu od 495,735 Da.[1][2][3][4][5][6][7][8][9][10][11][12]

Osobine

Osobina Vrednost
Broj akceptora vodonika 5
Broj donora vodonika 1
Broj rotacionih veza 23
Particioni koeficijent[13] (ALogP) 8,3
Rastvorljivost[14] (logS, log(mol/L)) -9,6
Polarna površina[15] (PSA, Å2) 81,7

Reference

  1. ^ Torgerson, J. S.; Hauptman, J.; Boldrin, M. N.; Sjöström, L. (2004 Jan). „XENical in the prevention of diabetes in obese subjects (XENDOS) study: A randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients”. Diabetes Care. 27 (1): 155—61. PMID 14693982. doi:10.2337/diacare.27.1.155.  Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  2. ^ Mancini, M. C.; Halpern, A. (2006 Apr). „Pharmacological treatment of obesity”. Arquivos Brasileiros de Endocrinologia e Metabologia. 50 (2): 377—89. PMID 16767304. doi:10.1590/s0004-27302006000200024.  Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  3. ^ Menendez, J. A.; Vellon, L.; Lupu, R. (2005 Aug). „Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: Blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/Neu (ErbB-2) oncogene”. Annals of Oncology : Official Journal of the European Society for Medical Oncology. 16 (8): 1253—67. PMID 15870086. doi:10.1093/annonc/mdi239.  Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  4. ^ Garcia, S. B.; Barros, L. T.; Turatti, A.; Martinello, F.; Modiano, P.; Ribeiro-Silva, A.; Vespúcio, M. V.; Uyemura, S. A. (2006 Aug 28). „The anti-obesity agent Orlistat is associated to increase in colonic preneoplastic markers in rats treated with a chemical carcinogen”. Cancer Letters. 240 (2): 221—4. PMID 16377080. doi:10.1016/j.canlet.2005.09.011.  Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  5. ^ Drew, B. S.; Dixon, A. F.; Dixon, J. B. (2007). „Obesity management: Update on orlistat”. Vascular Health and Risk Management. 3 (6): 817—21. PMC 2350121 Слободан приступ. PMID 18200802. 
  6. ^ Wong, N. N.; Cheng-Lai, A. (2000). „Orlistat”. Heart Disease (Hagerstown, Md.). 2 (2): 174—81. PMID 11728255. 
  7. ^ Hvizdos, K. M.; Markham, A. (1999 Oct). „Orlistat: A review of its use in the management of obesity”. Drugs. 58 (4): 743—60. PMID 10551441. doi:10.2165/00003495-199958040-00015.  Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  8. ^ Lucas, K. H.; Kaplan-Machlis, B. (2001 Mar). „Orlistat--a novel weight loss therapy”. The Annals of Pharmacotherapy. 35 (3): 314—28. PMID 11261530. doi:10.1345/aph.19412.  Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  9. ^ Curran, M. P.; Scott, L. J. (2004). „Orlistat: A review of its use in the management of patients with obesity”. Drugs. 64 (24): 2845—64. PMID 15563254. doi:10.2165/00003495-200464240-00010. 
  10. ^ Ballinger, A.; Peikin, S. R. (2002). „Orlistat: its current status as an anti-obesity drug”. European Journal of Pharmacology. 440 (2–3): 109—117. PMID 12007529. doi:10.1016/s0014-2999(02)01422-x. 
  11. ^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 Слободан приступ. PMID 21059682. doi:10.1093/nar/gkq1126. 
  12. ^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 Слободан приступ. PMID 18048412. doi:10.1093/nar/gkm958. 
  13. ^ . doi:10.1021/jp980230o.  Недостаје или је празан параметар |title= (помоћ)
  14. ^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  15. ^ Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura

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