Pioglitazon

Pioglitazon
Klinički podaci
Prodajno imeActos, Actost, Glustin
Drugs.comMonografija
Način primeneOralno
Identifikatori
CAS broj111025-46-8 Зелена квачицаДа
ATC kodA10BG03 (WHO)
PubChemCID 4829
IUPHAR/BPS2694
DrugBankDB01132 Зелена квачицаДа
ChemSpider4663 Зелена квачицаДа
KEGGC07675 Зелена квачицаДа
ChEBICHEBI:8228 Зелена квачицаДа
ChEMBLCHEMBL595 Зелена квачицаДа

Pioglitazon je organsko jedinjenje, koje sadrži 19 atoma ugljenika i ima molekulsku masu od 356,439 Da.[1][2][3][4][5]

Osobine

Osobina Vrednost
Broj akceptora vodonika 5
Broj donora vodonika 1
Broj rotacionih veza 7
Particioni koeficijent[6] (ALogP) 3,9
Rastvorljivost[7] (logS, log(mol/L)) -5,5
Polarna površina[8] (PSA, Å2) 93,6

Reference

  1. ^ Colca, J. R.; McDonald, W. G.; Waldon, D. J.; Leone, J. W.; Lull, J. M.; Bannow, C. A.; Lund, E. T.; Mathews, W. R. (2004). „Identification of a novel mitochondrial protein ("mitoNEET") cross-linked specifically by a thiazolidinedione photoprobe”. American Journal of Physiology. Endocrinology and Metabolism. 286 (2): E252—60. PMID 14570702. doi:10.1152/ajpendo.00424.2003. 
  2. ^ Paddock, M. L.; Wiley, S. E.; Axelrod, H. L.; Cohen, A. E.; Roy, M.; Abresch, E. C.; Capraro, D.; Murphy, A. N.; Nechushtai, R.; Dixon, J. E.; Jennings, P. A. (2007). „MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone”. Proceedings of the National Academy of Sciences of the United States of America. 104 (36): 14342—14347. Bibcode:2007PNAS..10414342P. PMC 1963346 Слободан приступ. PMID 17766440. doi:10.1073/pnas.0707189104 Слободан приступ. 
  3. ^ Lincoff, A. M.; Wolski, K.; Nicholls, S. J.; Nissen, S. E. (2007-09-12). „Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: A meta-analysis of randomized trials”. JAMA. 298 (10): 1180—8. PMID 17848652. doi:10.1001/jama.298.10.1180. 
  4. ^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 Слободан приступ. PMID 21059682. doi:10.1093/nar/gkq1126. 
  5. ^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 Слободан приступ. PMID 18048412. doi:10.1093/nar/gkm958. 
  6. ^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o. 
  7. ^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  8. ^ Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura

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