Primidon

Primidon
Klinički podaci
Prodajno imeApo-Primidone, Cyral, Desoxyphenobarbitone, Hexadiona
Drugs.comMonografija
Način primeneOralno
Identifikatori
CAS broj125-33-7 Зелена квачицаДа
ATC kodD08AC04 (WHO), N03AA03
PubChemCID 4909
DrugBankDB00794 Зелена квачицаДа
ChemSpider4740 Зелена квачицаДа
KEGGC07371 Зелена квачицаДа
ChEMBLCHEMBL856 Зелена квачицаДа

Primidon je organsko jedinjenje, koje sadrži 12 atoma ugljenika i ima molekulsku masu od 218,252 Da.[1][2][3][4][5][6][7]

Osobine

Osobina Vrednost
Broj akceptora vodonika 2
Broj donora vodonika 2
Broj rotacionih veza 2
Particioni koeficijent[8] (ALogP) 0,9
Rastvorljivost[9] (logS, log(mol/L)) -2,3
Polarna površina[10] (PSA, Å2) 58,2

Reference

  1. ^ Murphy K, Delanty N (2000 Nov). „Primary Generalized Epilepsies”. Curr Treat Options Neurol. 2 (6): 527—542. PMID 11096777. doi:10.1007/s11940-000-0031-0.  Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  2. ^ Kagitani-Shimono K, Imai K, Okamoto N, Ono J, Okada S: Unverricht-Lundborg disease with cystatin B gene abnormalities. Kagitani-Shimono, K.; Imai, K.; Okamoto, N.; Ono, J.; Okada, S. (2002 Jan). „Unverricht-Lundborg disease with cystatin B gene abnormalities”. Pediatr Neurol. 26 (1): 55—60. PMID 11814737. doi:10.1016/s0887-8994(01)00336-8.  Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  3. ^ Brown GM, Stone GH, Rathbone MP: Primidone and rapid cycling affective disorders. Lancet. Brown, G. M.; Stone, G. H.; Rathbone, M. P. (1993 Oct 9). „Primidone and rapid cycling affective disorders”. Lancet (London, England). 342 (8876): 925. PMID 8105181. doi:10.1016/0140-6736(93)91972-o.  Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  4. ^ Schaffer LC, Schaffer CB, Caretto J (1999 Jun). „The use of primidone in the treatment of refractory bipolar disorder”. Ann Clin Psychiatry. 11 (2): 61—6. PMID 10440522. doi:10.1023/a:1022338330606.  Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  5. ^ Young MC, Hughes IA (1991 Jan). „Loss of therapeutic control in congenital adrenal hyperplasia due to interaction between dexamethasone and primidone”. Acta Paediatr Scand. 80 (1): 120—4. PMID 2028784. doi:10.1111/j.1651-2227.1991.tb11744.x.  Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  6. ^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 Слободан приступ. PMID 21059682. doi:10.1093/nar/gkq1126. 
  7. ^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 Слободан приступ. PMID 18048412. doi:10.1093/nar/gkm958. 
  8. ^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o. 
  9. ^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  10. ^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura

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