Prostanoid

Prostanoid je podklasa eikozanoida koja obuhvata: prostaglandine (posrednike inflamatornih i anafilaktičkih reakcija), tromboksane (posrednike vazokonstrikcije) i prostacikline (aktivne u rezolucionoj fazi inflamacije).[1]

Biosinteza

Ciklooksigenaza (COX) katalizuje konverziju slobodnih esencijalnih masnih kiselina u prostanoide putem dvostepenog procesa. U prvom stepenu, dva molekula O2 se dodaju kao dve peroksidne veze i petočlani ugljenični prsten se formira blizo sredine lance masne kiseline. Time se formira kratkotrajni, nestabilni intermedijar prostaglandin G (PGG). Jedna od peroksidnih veza gubi jedan kiseonik, formirajući PGH. Svi drugi prostanoidi nastaju iz PGH (npr. PGH1, PGH2, i PGH3).

Slika pokazuje kako se PGH2 (derivat arahidonske kiseline) konvertuje:

Vidi još

Reference

  1. ^ Donald Voet; Judith G. Voet (2005). Biochemistry (3 изд.). Wiley. ISBN 9780471193500. 

Literatura

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