Relaksin

Relaxin 1
Identifikatori
SimbolRLN1
Alt. simboliH1
Entrez6013
HUGO10026
OMIM179730
RefSeqNM_006911
UniProtP04808
Ostali podaci
LokusHromozom 9 qter-q12
Relaxin 2
Identifikatori
SimbolRLN2
Alt. simboliH2, RLXH2, bA12D24.1.1, bA12D24.1.2
Entrez6019
HUGO10027
OMIM179740
PDB6RLX
RefSeqNM_134441
UniProtP04090
Ostali podaci
LokusHromozom 9 qter-q12
Relaxin 3
Identifikatori
SimbolRLN3
Alt. simboliZINS4, RXN3, H3
Entrez117579
HUGO17135
OMIM606855
RefSeqNM_080864
UniProtQ8WXF3
Ostali podaci
LokusHromozom 19 p13.3

Relaksin je proteinski hormon koji je prvi put opisan 1926.[1][2]

Relaksinu-slična peptidna familija pripada insulinskoj familiji, i sastoji se od 7 peptida koji imaju visoku strukturnu sličnost, mada se njihove sekvence znatno razlikuju. Relaksin-1 (RNL1), 2 (RNL2) i 3 (RNL3), i insulinu-slični (INSL) peptidi, INSL3, INSL4, INSL5 i INSL6. Funkcije relaksina-3, INSL4, INSL5, INSL6 još uvek nisu razjašnjene.[3]

Sinteza

Relaksin kod žena proizvodi corpus luteum jajnika, dojke i, tokom trudnoće isto tako materica, horion, i decidua. Kod muškaraca, njega proizvodi prostata, i prisutan je u ljudskim semenu.[4]

Struktura

Strukturno, relaksin je heterodimer dva peptidna lanca sa 24 i 29 aminokiselina vezana disulfidnim mostovima. On je srodan sa insulinom.

Relaksin nastaje iz njegovog prohormona, prorelaksina, putem odvajanja jednog dodatnog peptidnog lanca.

Poremećaji

Poremećaji specifično vezani za relaksin nisu poznati, mada postoje veze sa sklerodermom i fibromialgijom.[5]

Reference

  1. ^ „If a Gopher Can Do It ...”. Time Magazine. 10. 4. 1944. Архивирано из оригинала 15. 12. 2008. г. Приступљено 20. 5. 2009. 
  2. ^ Becker GJ, Hewitson TD (2001). „Relaxin and renal fibrosis”. Kidney Int.. 59 (3): 1184—5. PMID 11231378. doi:10.1046/j.1523-1755.2001.0590031184.x. 
  3. ^ Wilkinson TN, Speed TP, Tregear GW, Bathgate RA (2005). „Evolution of the relaxin-like peptide family”. BMC evolutionary biology. 5 (1): 14. PMC 551602 Слободан приступ. PMID 15707501. doi:10.1186/1471-2148-5-14. 
  4. ^ MacLennan, AH (1991). „The role of the hormone relaxin in human reproduction and pelvic girdle relaxation”. Scandinavian journal of rheumatology. Supplement. 88: 7—15. PMID 2011710. 
  5. ^ Van Der Westhuizen E, Summers R, Halls M, Bathgate R, Sexton P (2007). „Relaxin receptors--new drug targets for multiple disease states”. Curr Drug Targets. 8 (1): 91—104. PMID 17266534. doi:10.2174/138945007779315650. 

Spoljašnje veze

  • Relaxin на US National Library of Medicine Medical Subject Headings (MeSH)
  • „Relaxin”. Human Protein Reference Database. Johns Hopkins University and the Institute of Bioinformatics. Архивирано из оригинала 29. 11. 2014. г. Приступљено 20. 5. 2009. 

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.