Toremifen

Toremifen
Klinički podaci
Prodajno imeAcapodene, Farestone, Toremifene Base, Toremifeno [Spanish]
Drugs.comMonografija
Način primeneOralno
Identifikatori
CAS broj89778-26-7 Зелена квачицаДа
ATC kodL02BA02 (WHO)
PubChemCID 3005573
DrugBankDB00539 Зелена квачицаДа
ChemSpider2275722 Зелена квачицаДа
KEGGC08166 Зелена квачицаДа
ChEBICHEBI:9635 Зелена квачицаДа
ChEMBLCHEMBL1655 Зелена квачицаДа

Toremifen je organsko jedinjenje, koje sadrži 26 atoma ugljenika i ima molekulsku masu od 405,960 Da.[1][2][3][4][5][6][7]

Osobine

Osobina Vrednost
Broj akceptora vodonika 2
Broj donora vodonika 0
Broj rotacionih veza 9
Particioni koeficijent[8] (ALogP) 6,3
Rastvorljivost[9] (logS, log(mol/L)) -8,2
Polarna površina[10] (PSA, Å2) 12,5

Reference

  1. ^ Price N, Sartor O, Hutson T, Mariani S (2005 Mar). „Role of 5a-reductase inhibitors and selective estrogen receptor modulators as potential chemopreventive agents for prostate cancer”. Clin Prostate Cancer. 3 (4): 211—4. PMID 15882476.  Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  2. ^ Taneja SS, Smith MR, Dalton JT, Raghow S, Barnette G, Steiner M, Veverka KA (2006 Mar). „Toremifene--a promising therapy for the prevention of prostate cancer and complications of androgen deprivation therapy”. Expert Opin Investig Drugs. 15 (3): 293—305. PMID 16503765.  Проверите вредност парамет(а)ра за датум: |date= (помоћ)
  3. ^ Thompson IM: Chemoprevention of prostate cancer: agents and study designs. J Urol. 2007 Sep;178(3 Pt 2):S9-S13. Epub 2007 Jul 20. . PMID 17644117.  Недостаје или је празан параметар |title= (помоћ)
  4. ^ Ariazi EA, Ariazi JL, Cordera F, Jordan VC (2006). „Estrogen receptors as therapeutic targets in breast cancer”. Curr Top Med Chem. 6 (3): 181—202. PMID 16515478. 
  5. ^ Musa MA, Khan MO, Cooperwood JS (2007). „Medicinal chemistry and emerging strategies applied to the development of selective estrogen receptor modulators (SERMs)”. Curr Med Chem. 14 (11): 1249—61. PMID 17504144. 
  6. ^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 Слободан приступ. PMID 21059682. doi:10.1093/nar/gkq1126. 
  7. ^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 Слободан приступ. PMID 18048412. doi:10.1093/nar/gkm958. 
  8. ^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o. 
  9. ^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  10. ^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura

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