During the Sengoku period, the Mori served under Oda Nobunaga. Mori Yoshinari fought with Nobunaga for Kiyosu Castle, and with his son Mori Yoshitaka joined the campaigns against the Saitō, Azai, and Asakura. Father and son died in the battle against the Azai-Asakura armies, and Mori Nagayoshi, second son of Yoshinari, became head of the house.