Fenhizon

Fenhizon
Klinički podaci
Drugs.comMonografija
Identifikatori
ATC kodC03BA13 (WHO)
PubChemCID 68548
ChemSpider61822 Зелена квачицаДа
UNIILJ1U13R8IK Зелена квачицаДа
KEGGD04161 Зелена квачицаДа

Fenhizon (INN) je diuretik, deo klase sulfonamidnih diuretika.[1] Fenhizon se prvenstveno koristi u lečenju edema i hipertenzije.[2]

Osobine

Fenhizon je organsko jedinjenje, koje sadrži 14 atoma ugljenika i ima molekulsku masu od 337,781 Da.

Osobina Vrednost
Broj akceptora vodonika 5
Broj donora vodonika 3
Broj rotacionih veza 2
Particioni koeficijent[3] (ALogP) 2,5
Rastvorljivost[4] (logS, log(mol/L)) -4,4
Polarna površina[5] (PSA, Å2) 113,2

Reference

  1. ^ Ferrando C, Foy JM, Pratt CN, Purvis JR (април 1981). „On the pharmacological actions of a diuretic, fenquizone, with particular reference to its site of action”. The Journal of Pharmacy and Pharmacology. 33 (4): 219—22. PMID 6115903. doi:10.1111/j.2042-7158.1981.tb13761.x. 
  2. ^ „Fenquizone”. Drug Information from MIMS. Thailand. [мртва веза]
  3. ^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o. 
  4. ^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  5. ^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura

Spoljašnje veze

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