INHA
| Inhibin, alfa | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simbol | INHA | ||||||||||
| Vanjski ID | OMIM: 147380 MGI: 96569 HomoloGene: 1652 GeneCards: INHA Gene | ||||||||||
| |||||||||||
| Pregled RNK izražavanja | |||||||||||
 | |||||||||||
| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 3623 | 16322 | |||||||||
| Ensembl | ENSG00000123999 | ENSMUSG00000032968 | |||||||||
| UniProt | P05111 | Q04997 | |||||||||
| RefSeq (mRNA) | NM_002191.3 | NM_010564.4 | |||||||||
| RefSeq (protein) | NP_002182.1 | NP_034694.3 | |||||||||
| Lokacija (UCSC) |
Chr 2: 220.43 - 220.44 Mb |
Chr 1: 75.51 - 75.51 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Inhibin, alfa (INHA) je protein koji je kod ljudi kodiran INHA genom.[1]
Funkcija
Inhibin alfa podjedinica zajedno sa još jednom beta A ili beta B podjedinicom formira hipofizni FSH sekretorni inhibitor. Inhibin negativno reguliše proliferaciju gonadalnih stromalnih ćelija i ima supresivno dejstvo na tumour. Serumski nivoi inhibina odražavaju veličinu granulosa-ćelija tumora i mogu se koristiti kao marker za primarnu kao i rekurentnu bolest. Kod kancera prostate, izražavanje gena inhibin alfa-podjedinice je potisnuto i ne može se detektovati kod slabo diferenciranih ćelija tumora.[2]
Reference
- ^ Burger HG, Igarashi M (1988). „Inhibin: definition and nomenclature, including related substances”. Endocrinology. 122 (4): 1701—2. PMID 3345731. doi:10.1210/endo-122-4-1701.
- ^ „Entrez Gene: INHA inhibin, alpha”.
Literatura
- Mellor SL; Richards MG; Pedersen JS; et al. (1998). „Loss of the expression and localization of inhibin alpha-subunit in high grade prostate cancer”. J. Clin. Endocrinol. Metab.. 83 (3): 969—75. PMID 9506758. doi:10.1210/jc.83.3.969.
- Munz B; Hübner G; Tretter Y; et al. (1999). „A novel role of activin in inflammation and repair”. J. Endocrinol.. 161 (2): 187—93. PMID 10320815. doi:10.1677/joe.0.1610187.
- Welt C, Sidis Y, Keutmann H, Schneyer A (2002). „Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium”. Exp. Biol. Med. (Maywood). 227 (9): 724—52. PMID 12324653.
- Shav-Tal Y, Zipori D (2003). „The role of activin a in regulation of hemopoiesis”. Stem Cells. 20 (6): 493—500. PMID 12456957. doi:10.1634/stemcells.20-6-493.
- Shao L; Frigon NL; Young AL; et al. (1992). „Effect of activin A on globin gene expression in purified human erythroid progenitors”. Blood. 79 (3): 773—81. PMID 1310063.
- Vannelli GB; Barni T; Forti G; et al. (1992). „Immunolocalization of inhibin alpha-subunit in the human testis. A light- and electron-microscopy study”. Cell Tissue Res.. 269 (2): 221—7. PMID 1423490.
- Matzuk MM; Finegold MJ; Su JG; et al. (1992). „Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice”. Nature. 360 (6402): 313—9. PMID 1448148. doi:10.1038/360313a0.
- Shimonaka M, Inouye S, Shimasaki S, Ling N (1991). „Follistatin binds to both activin and inhibin through the common subunit”. Endocrinology. 128 (6): 3313—5. PMID 2036994. doi:10.1210/endo-128-6-3313.
- Mason AJ, Berkemeier LM, Schmelzer CH, Schwall RH (1990). „Activin B: precursor sequences, genomic structure and in vitro activities”. Mol. Endocrinol.. 3 (9): 1352—8. PMID 2575216. doi:10.1210/mend-3-9-1352.
- Barton DE; Yang-Feng TL; Mason AJ; et al. (1989). „Mapping of genes for inhibin subunits alpha, beta A, and beta B on human and mouse chromosomes and studies of jsd mice”. Genomics. 5 (1): 91—9. PMID 2767687. doi:10.1016/0888-7543(89)90091-8.
- Lappöhn RE; Burger HG; Bouma J; et al. (1989). „Inhibin as a marker for granulosa-cell tumors”. N. Engl. J. Med.. 321 (12): 790—3. PMID 2770810. doi:10.1056/NEJM198909213211204.
- Mayo KE; Cerelli GM; Spiess J; et al. (1986). „Inhibin A-subunit cDNAs from porcine ovary and human placenta”. Proc. Natl. Acad. Sci. U.S.A.. 83 (16): 5849—53. PMC 386393
. PMID 3016724. doi:10.1073/pnas.83.16.5849. - Ramasharma K, Li CH (1987). „Characteristics of binding of human seminal alpha-inhibin-92 to human pituitary membranes”. Proc. Natl. Acad. Sci. U.S.A.. 84 (11): 3595—8. PMC 304921 . PMID 3035540. doi:10.1073/pnas.84.11.3595.
- Murata M; Eto Y; Shibai H; et al. (1988). „Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain”. Proc. Natl. Acad. Sci. U.S.A.. 85 (8): 2434—8. PMC 280011 . PMID 3267209. doi:10.1073/pnas.85.8.2434.
- Burger HG, Igarashi M (1988). „Inhibin: definition and nomenclature, including related substances”. Endocrinology. 122 (4): 1701—2. PMID 3345731. doi:10.1210/endo-122-4-1701.
- Mason AJ, Niall HD, Seeburg PH (1986). „Structure of two human ovarian inhibins”. Biochem. Biophys. Res. Commun.. 135 (3): 957—64. PMID 3754442. doi:10.1016/0006-291X(86)91021-1.
- Stewart AG; Milborrow HM; Ring JM; et al. (1986). „Human inhibin genes. Genomic characterisation and sequencing”. FEBS Lett.. 206 (2): 329—34. PMID 3758355. doi:10.1016/0014-5793(86)81006-7.
- Xu J, McKeehan K, Matsuzaki K, McKeehan WL (1995). „Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism”. J. Biol. Chem.. 270 (11): 6308—13. PMID 7890768. doi:10.1074/jbc.270.11.6308.
- Nishihara T, Okahashi N, Ueda N (1994). „Activin A induces apoptotic cell death”. Biochem. Biophys. Res. Commun.. 197 (2): 985—91. PMID 8267637. doi:10.1006/bbrc.1993.2576.
- Mason AJ, Farnworth PG, Sullivan J (1997). „Characterization and determination of the biological activities of noncleavable high molecular weight forms of inhibin A and activin A”. Mol. Endocrinol.. 10 (9): 1055—65. PMID 8885240. doi:10.1210/me.10.9.1055.
Vidi još
Content Disclaimer
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
- The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
- There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
- It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
- Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
- Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.