Metformin

Metformin
Nazivi
Drugi nazivi
Apo-Metformin, Fortamet, Gen-Metformin, Glucophage
Identifikacija
3D model (Jmol)
ChEBI
ChemSpider
DrugBank
ECHA InfoCard 100.010.472
KEGG[1]
  • CN(C)C(=N)NC(N)=N
Svojstva
C4H11N5
Molarna masa 129,164
Tačka topljenja 223-226
Farmakologija
Oralno
Farmakokinetika:
8-12 h
Renalno
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
Зелена квачицаДа verifikuj (šta je Зелена квачицаДаRed КрстићНе ?)
Reference infokutije

Metformin je organsko jedinjenje, koje sadrži 4 atoma ugljenika i ima molekulsku masu od 129,164 Da.[4][5][6][7][8][9][10]

Osobine

Osobina Vrednost
Broj akceptora vodonika 2
Broj donora vodonika 4
Broj rotacionih veza 3
Particioni koeficijent[11] (ALogP) -0,7
Rastvorljivost[12] (logS, log(mol/L)) 1,6
Polarna površina[13] (PSA, Å2) 89,0

Reference

  1. ^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  2. ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  уреди
  3. ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1. 
  4. ^ Witters LA (октобар 2001). „The blooming of the French lilac”. J Clin Invest. 108 (8): 1105—7. PMC 209536 Слободан приступ. PMID 11602616. doi:10.1172/JCI14178. 
  5. ^ UNGAR G, FREEDMAN L, SHAPIRO SL (мај 1957). „Pharmacological studies of a new oral hypoglycemic drug”. Proc Soc Exp Biol Med. 95 (1): 190—2. PMID 13432032. doi:10.3181/00379727-95-23163. 
  6. ^ Lord JM, Flight IH, Norman RJ: Metformin in polycystic ovary syndrome: systematic review and meta-analysis. BMJ. 25;Lord, J. M.; Flight, I. H.; Norman, R. J. (октобар 2003). „Metformin in polycystic ovary syndrome: Systematic review and meta-analysis”. BMJ (Clinical Research Ed.). 327 (7421): 951—3. PMC 259161 Слободан приступ. PMID 14576245. doi:10.1136/bmj.327.7421.951. 
  7. ^ Marchesini G, Brizi M, Bianchi G, Tomassetti S, Zoli M, Melchionda N: Metformin in non-alcoholic steatohepatitis. Lancet. 15;Marchesini, G.; Brizi, M.; Bianchi, G.; Tomassetti, S.; Zoli, M.; Melchionda, N. (септембар 2001). „Metformin in non-alcoholic steatohepatitis”. Lancet (London, England). 358 (9285): 893—4. PMID 11567710. doi:10.1016/s0140-6736(01)06042-1. 
  8. ^ Nair S, Diehl AM, Wiseman M, Farr GH Jr, Perrillo RP (јул 2004). „Metformin in the treatment of non-alcoholic steatohepatitis: a pilot open label trial”. Aliment Pharmacol Ther. 20 (1): 23—8. PMID 15225167. doi:10.1111/j.1365-2036.2004.02025.x. 
  9. ^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 Слободан приступ. PMID 21059682. doi:10.1093/nar/gkq1126. 
  10. ^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 Слободан приступ. PMID 18048412. doi:10.1093/nar/gkm958. 
  11. ^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o. 
  12. ^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  13. ^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura

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