NPR1
| Natriuretski peptidni receptor A/guanilat ciklaza A (atrionatriuretski peptidni receptor A) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | NPR1; ANPRA; ANPa; GUC2A; GUCY2A; NPRA | ||||||||||
| Vanjski ID | OMIM: 108960 MGI: 97371 HomoloGene: 37367 GeneCards: NPR1 Gene | ||||||||||
| EC broj | 4.6.1.2 | ||||||||||
| |||||||||||
| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 4881 | 18160 | |||||||||
| Ensembl | ENSG00000169418 | ENSMUSG00000027931 | |||||||||
| UniProt | P16066 | P18293 | |||||||||
| RefSeq (mRNA) | NM_000906.3 | NM_008727.5 | |||||||||
| RefSeq (protein) | NP_000897.3 | NP_032753.5 | |||||||||
| Lokacija (UCSC) |
Chr 1: 153.65 - 153.67 Mb |
Chr 3: 90.45 - 90.47 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Natriuretski peptidni receptor A (atrionatriuretski peptidni receptor A, NPR1) je receptor atrijalnog natriuretskog peptida. Ovaj receptor je kod čoveka kodiran NPR1 genom.
Funkcija
NPR1 je membranska guanilatna ciklaza koja služi kao receptor za atrijalne i moždane natriuretske peptide (ANP i BNP, respektivno).[1]
On je lokalizovan u bubrezima[2] gde doprinosi nautriurezi nakon vezivanja natriuretskih peptida. On je u znatnoj meri zastupljen u plučima i adipocitima.[2]
Reference
- ^ „Entrez Gene: NPR1 natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)”.
- ^ а б BioGPS > NPR1 Архивирано на веб-сајту Wayback Machine (30. децембар 2009) Retrieved Nov 2010
Literatura
- Pandey KN (2002). „Intracellular trafficking and metabolic turnover of ligand-bound guanylyl cyclase/atrial natriuretic peptide receptor-A into subcellular compartments.”. Mol. Cell. Biochem.. 230 (1–2): 61—72. PMID 11952097. doi:10.1023/A:1014240006767.
- Lucarelli K; Iacoviello M; Dessì-Fulgheri P; et al. (2003). „[Natriuretic peptides and essential arterial hypertension]”. Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology. 3 (11): 1085—91. PMID 12506509.
- Pandey KN (2005). „Internalization and trafficking of guanylyl cyclase/natriuretic peptide receptor-A”. Peptides. 26 (6): 985—1000. PMID 15911067. doi:10.1016/j.peptides.2004.12.020.
- Garg R, Pandey KN (2005). „Regulation of guanylyl cyclase/natriuretic peptide receptor-A gene expression”. Peptides. 26 (6): 1009—23. PMID 15911069. doi:10.1016/j.peptides.2004.09.022.
Vidi još
Spoljašnje veze
- NPR1+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)
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