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Fosfofruktokinaza, jetra
Fosfofruktokinaza, jetra
Identifikatori
Simboli	PFKL; ATP-PFK; PFK-B; PFK-L
Vanjski ID	OMIM: 171860 MGI: 97547 HomoloGene: 55668 GeneCards: PFKL Gene
EC broj	2.7.1.11
Ontologija gena
Molekularna funkcija	• 6-fosfofruktokinazna aktivnost; • proteinsko vezivanje; • ATP vezivanje;
Celularna komponenta	• citosol; • 6-fosfofruktokinazni kompleks; • membrana;
Biološki proces	• ugljenohidratni metabolički proces; • fruktoza 6-fosfatni metabolički proces; • glukozni metabolički proces;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	5211
Ensembl	ENSG00000141959
UniProt	P17858
RefSeq (mRNA)	NM_001002021
RefSeq (protein)	NP_001002021
Lokacija (UCSC)	Chr 21:; 45.72 - 45.75 Mb
PubMed pretraga	[1]

6-Fosfofruktokinaza, jetreni tip je enzim koji je kod ljudi kodiran PFKL genom.^[1]

Fosfofruktokinaza (PFK) je tetramerni enzim koji katalizuje ključni korak u glikolizi, konverziju D-fruktoze 6-fosfata do D-fruktoze 1,6-bisfosfata. Zasebni genei kodiraju mišićnu podjedinicu (M) i jetrenu podjedinicu (L). PFK iz mišića je homotetramer M podjedinica, PFK iz jetre je homotetramer L-jedinica, dok se PFK iz trombocita može sastojati od bilo koje tetramerne kombinacije M i L podjedinica. Protein kodiran ovim genom je L podjedinica. Dve transkriptne varijante koje kodiraju različite izoforme su poznate.^[1]

Reference

^ ^а ^б „Entrez Gene: PFKL phosphofructokinase, liver”.

Literatura

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[entrez-1] а ^б „Entrez Gene: PFKL phosphofructokinase, liver”.

[1]

PFKL

Reference

Literatura

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