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Fosfofruktokinaza, trombocit
Fosfofruktokinaza, trombocit
Identifikatori
Simboli	PFKP; ATP-PFK; PFK-C; PFK-P; PFKF
Vanjski ID	OMIM: 171840 MGI: 1891833 HomoloGene: 20579 GeneCards: PFKP Gene
EC broj	2.7.1.11
Ontologija gena
Molekularna funkcija	• 6-fosfofruktokinazna aktivnost; • ATP vezivanje; • vezivanje proteinskog kompleksa;
Celularna komponenta	• nukleus; • citosol; • 6-fosfofruktokinazni kompleks;
Biološki proces	• ugljenohidratni metabolički proces; • fruktoza 6-fosfatni metabolički proces; • glukozni metabolički proces;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	5214
Ensembl	ENSG00000067057
UniProt	Q01813
RefSeq (mRNA)	NM_001242339
RefSeq (protein)	NP_001229268
Lokacija (UCSC)	Chr 10:; 3.11 - 3.18 Mb
PubMed pretraga	[1]

Fosfofruktokinaza, trombocitni tip, takođe poznata kao PFKP je enzim koji je kod ljudi kodiran PFKP genom.^[1]

Funkcija

PFKP gen kodira trombocitnu izoformu fosfofruktokinaze (PFK) (ATP:D-fruktoza-6-fosfat-1-fosfotransferaza, EC 2.7.1.11). PFK katalizujue ireverzibilnu konverziju fruktoza 6-fosfata do fruktoza 1,6-bisfosfata i ključni je regulatorni enzim u glikolizi. PFKP gen, koji je mapiran na hromozomu 10p, je isto tako izražen u fibroblastima. Mišićna (PFKM) i jetrena (PFKL) izoforma fosfofruktokinaze su locirane na hromozomima 12q13 i 21q22, respektivno. Completni tetramerni fosfofruktokinazni enzim koji je prisutan u trombocitima može da bude formiran od podjedinica P4, P3L, i P2L2.^[2]^[1]

Reference

^ ^а ^б „Entrez Gene: PFKP phosphofructokinase, platelet”.
^ Vora S (1981). „Isozymes of human phosphofructokinase in blood cells and cultured cell lines: molecular and genetic evidence for a trigenic system”. Blood. 57 (4): 724—32. PMID 6451249. ^{[мртва веза]}

Literatura

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Morrison N; Simpson C; Fothergill-Gilmore L; et al. (1992). „Regional chromosomal assignment of the human platelet phosphofructokinase gene to 10p15”. Hum. Genet.. 89 (1): 105—6. PMID 1533608. doi:10.1007/BF00207053.
Simpson CJ, Fothergill-Gilmore LA (1991). „Isolation and sequence of a cDNA encoding human platelet phosphofructokinase”. Biochem. Biophys. Res. Commun.. 180 (1): 197—203. PMID 1834056. doi:10.1016/S0006-291X(05)81276-8.
Nakajima H; Noguchi T; Yamasaki T; et al. (1987). „Cloning of human muscle phosphofructokinase cDNA”. FEBS Lett.. 223 (1): 113—6. PMID 2822475. doi:10.1016/0014-5793(87)80519-7.
Eto K; Sakura H; Yasuda K; et al. (1994). „Cloning of a complete protein-coding sequence of human platelet-type phosphofructokinase isozyme from pancreatic islet”. Biochem. Biophys. Res. Commun.. 198 (3): 990—8. PMID 8117307. doi:10.1006/bbrc.1994.1141.
Bonaldo MF, Lennon G, Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Res.. 6 (9): 791—806. PMID 8889548. doi:10.1101/gr.6.9.791.
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Beausoleil SA; Jedrychowski M; Schwartz D; et al. (2004). „Large-scale characterization of HeLa cell nuclear phosphoproteins”. Proc. Natl. Acad. Sci. U.S.A.. 101 (33): 12130—5. PMC 514446 . PMID 15302935. doi:10.1073/pnas.0404720101.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res.. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
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Hannemann A; Jandrig B; Gaunitz F; et al. (2005). „Characterization of the human P-type 6-phosphofructo-1-kinase gene promoter in neural cell lines”. Gene. 345 (2): 237—47. PMID 15716112. doi:10.1016/j.gene.2004.11.018.
Beausoleil SA; Villén J; Gerber SA; et al. (2006). „A probability-based approach for high-throughput protein phosphorylation analysis and site localization”. Nat. Biotechnol.. 24 (10): 1285—92. PMID 16964243. doi:10.1038/nbt1240.
Ewing RM; Chu P; Elisma F; et al. (2007). „Large-scale mapping of human protein–protein interactions by mass spectrometry”. Mol. Syst. Biol.. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134.
Martínez-Costa OH, Sánchez-Martínez C, Sánchez V, Aragón JJ (2007). „Chimeric phosphofructokinases involving exchange of the N- and C-terminal halves of mammalian isozymes: implications for ligand binding sites”. FEBS Lett.. 581 (16): 3033—8. PMID 17544406. doi:10.1016/j.febslet.2007.05.059.

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ATP-PFK

[entrez-1] а ^б „Entrez Gene: PFKP phosphofructokinase, platelet”.

[pmid6451249-2] Vora S (1981). „Isozymes of human phosphofructokinase in blood cells and cultured cell lines: molecular and genetic evidence for a trigenic system”. Blood. 57 (4): 724—32. PMID 6451249. ^{[мртва веза]}

[1]

[2]

PFKP

Funkcija

Reference

Literatura

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