Transferin

Transferin
PDB prikaz baziran na 1a8e​.
Dostupne strukture
1A8E​, 1A8F​, 1B3E​, 1BP5​, 1BTJ​, 1D3K​, 1D4N​, 1DTG​, 1FQE​, 1FQF​, 1JQF​, 1N7W​, 1N7X​, 1N84​, 1OQG​, 1OQH​, 1RYO​, 1SUV​, 2HAU​, 2HAV​, 2O7U​, 2O84​, 3FGS​
Identifikatori
Simboli TF; DKFZp781D0156; PRO1557; PRO2086
Vanjski ID OMIM: 190000 MGI: 98821 HomoloGene: 68153 GeneCards: TF Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 7018 22041
Ensembl ENSG00000091513 ENSMUSG00000032554
UniProt P02787 Q3UBW7
RefSeq (mRNA) NM_001063.3 NM_133977.2
RefSeq (protein) NP_001054.1 NP_598738.1
Lokacija (UCSC) Chr 3:
133.46 - 133.5 Mb		 Chr 9:
103.11 - 103.13 Mb
PubMed pretraga [1] [2]
Transferin
Identifikatori
SimbolTransferrin
PfamPF00405
InterProIPR001156
PROSITEPDOC00182
SCOP1lcf
SUPERFAMILY1lcf

Transferin (siderofilin) je transportni protein gvožđa u plazmi.[1] Kod ljudi je kodiran TF genom.[2] Transportuje ga od mjesta apsorpcije i mesta razgradnje do mesta eritropoeze (koštana srž). Normalno je oko 30% transferina zasićeno gvožđem.

Transferin ima relativnu molekulsku masu 77 000. Sintetiše se najviše u jetri, manjim delom retikuloendotelnom sistemu i endokrinim žlezdama (testisi, ovariji). Poluživot mu je 7,5 dana, a mesto katabolizma je nepoznato. Osim katjona gvožđa transferin vezuje i katjone bakra, cinka, kobalta i kalcijuma. Fiziološki značaj ima jedino vezanje gvožđa i bakra. Određivanje sadržaja transferina bitno je za diferencijalnu dijagnozu anemija i za praćenja efekta terapija pri lečenju anemija.

Reference

  1. ^ Crichton RR, Charloteaux-Wauters M (1987). „Iron transport and storage”. Eur. J. Biochem.. 164 (3): 485—506. PMID 3032619. doi:10.1111/j.1432-1033.1987.tb11155.x. 
  2. ^ Yang F, Lum JB, McGill JR, Moore CM, Naylor SL, van Bragt PH, Baldwin WD, Bowman BH (1984). „Human transferrin: cDNA characterization and chromosomal localization”. Proceedings of the National Academy of Sciences of the United States of America. 81 (9): 2752—6. PMC 345148 Слободан приступ. PMID 6585826. doi:10.1073/pnas.81.9.2752. 

Literatura

  • Hershberger CL; Larson JL; Arnold B; et al. (1992). „A cloned gene for human transferrin”. Ann. N. Y. Acad. Sci.. 646: 140—54. PMID 1809186. doi:10.1111/j.1749-6632.1991.tb18573.x. 
  • Bowman BH, Yang FM, Adrian GS (1989). „Transferrin: evolution and genetic regulation of expression”. Adv. Genet.. 25: 1—38. PMID 3057819. doi:10.1016/S0065-2660(08)60457-5. 
  • Parkkinen J, von Bonsdorff L, Ebeling F, Sahlstedt L (2003). „Function and therapeutic development of apotransferrin”. Vox Sang.. 83 (Suppl 1): 321—6. PMID 12617162. 

Spoljašnje veze

  • Transferrin на US National Library of Medicine Medical Subject Headings (MeSH)

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