Triptaza

Triptaza
alpha1 Triptaza tetramer, Human
Identifikatori
EC broj3.4.21.59
CAS broj97501-93-4
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum

Triptaza (EC 3.4.21.59, mastocitna proteaza II, kožna triptaza, plućna triptaza, pljuvačna triptaza, mastocitna neutralna proteinaza, mastocitna triptaza, mastocitna neutralna proteinaza, mastocitna serinska proteinaza II, mastocitna proteinaza II, mastocitna serinska proteinazna triptaza, mastocitna proteaza II pacova, triptaza M) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Preferencijalno razlaganje veza: Arg-, Lys-, ali sa ograničenijom specifičnošću od tripsina

Ovaj enzim se javalja kao tetramerni molekul sa visokim afinitetom za heparin u mastocitnim granulama.

Reference

  1. ^ Tanaka, T., McRae, B.J., Cho, K., Cook, R., Fraki, J.E., Johnson, D.A. and Powers, J.C. (1983). „Mammalian tissue trypsin-like enzymes. Comparative reactivities of human skin tryptase, human lung tryptase, and bovine trypsin with peptide 4-nitroanilide and thioester substrates”. J. Biol. Chem.. 258: 13552—13557. PMID 6358206. 
  2. ^ Kido, H., Fukusen, N. and Katunuma, N. (1985). „Chymotrypsin- and trypsin-type serine proteases in rat mast cells: properties and functions”. Arch. Biochem. Biophys. 239: 436—443. PMID 3890754. 
  3. ^ Cromlish, J.A., Seidah, N.G., Marcinkiewitz, M., Hamelin, J., Johnson, D.A. and Chrétien, M. (1987). „Human pituitary tryptase: molecular forms, NH2-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates”. J. Biol. Chem.. 262: 1363—1373. PMID 3543004. 
  4. ^ Harvima, I.T., Schechter, N.M., Harvima, R.J. and Fräki, J.E. (1988). „Human skin tryptase: purification, partial characterization and comparison with human lung tryptase”. Biochim. Biophys. Acta. 957: 71—80. PMID 3140898. 
  5. ^ Vanderslice, P., Ballinger, S.M., Tam, E.K., Goldstein, S.M., Craik, C.S. and Caughey, G. (1990). „Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family”. Proc. Natl. Acad. Sci. USA. 87: 3811—3815. PMID 2187193. 

Literatura

Spoljašnje veze

  • Tryptase на US National Library of Medicine Medical Subject Headings (MeSH)

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