DDR1
| Diskoidin domen receptor familija, izoforma 1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | DDR1; CAK; CD167; DDR; EDDR1; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE | ||||||||||
| Vanjski ID | OMIM: 600408 MGI: 99216 HomoloGene: 68212 GeneCards: DDR1 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 780 | 12305 | |||||||||
| Ensembl | ENSG00000137332 | ENSMUSG00000003534 | |||||||||
| UniProt | Q08345 | O35407 | |||||||||
| RefSeq (mRNA) | NM_001954 | NM_007584 | |||||||||
| RefSeq (protein) | NP_001945 | NP_031610 | |||||||||
| Lokacija (UCSC) |
Chr c6_COX: 30.99 - 31.01 Mb |
Chr 17: 35.29 - 35.31 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
DDR1, ili CD167a (klaster diferencijacije 167a), je ljudski gen[1] koji je pripadnik broj 1 familije diskoidin domen receptora.
Receptor tirozin kinaze (RTK) igraju ključnu ulogu u komunikaciji ćelija sa njihovim mikro okruženjem. Ti molekuli su uključeni u regulaciju ćelijskog rasta, diferencijacije i metabolizma. Protein kodiran ovim genom je RTK koji je široko izražen u normalnim i transformisanim epitelnim ćelijama, i koji je aktiviran kolagenom. Ovaj protein pripada potfamiliji receptora tirozin kinaza koje sadrže homologni region sa Dictyostelium discoideum proteinom diskoidin I u njihovom ekstracelularnom domenu. Njegova auto-fosforilacija se postiže svim do sada testiranim kolagenima (tip I - VI). In situ studije i Northern-blot analiza su pokazale da je izražavanje ovog protein ograničeno na epitelske ćelije, posebno u bubrezima, plućima, gastrointestinalnom traktu, i mozgu. Dodatno, ovaj protein je značajno preizražen i u nekoliko ljudskih tumora iz dojki, jajnika, jednjaka, pedijatrijskog mozga. Ovaj gen se nalazi na hromozomu 6p21.3 u blizini nekoliko HLA klasa I gena. Alternativno splajsovanje (engl. splicing) ovog gena proizvodi nekoliko transkript varijanti.[1]
Reference
Literatura
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- Shelling AN; Butler R; Jones T; et al. (1995). „Localization of an epithelial-specific receptor kinase (EDDR1) to chromosome 6q16.”. Genomics. 25 (2): 584—7. PMID 7789998. doi:10.1016/0888-7543(95)80065-T.
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- Sakuma S; Saya H; Tada M; et al. (1997). „Receptor protein tyrosine kinase DDR is up-regulated by p53 protein.”. FEBS Lett.. 398 (2-3): 165—9. PMID 8977099. doi:10.1016/S0014-5793(96)01234-3.
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- Vogel W, Gish GD, Alves F, Pawson T (1998). „The discoidin domain receptor tyrosine kinases are activated by collagen.”. Mol. Cell. 1 (1): 13—23. PMID 9659899. doi:10.1016/S1097-2765(00)80003-9.
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- Vogel W; Brakebusch C; Fässler R; et al. (2000). „Discoidin domain receptor 1 is activated independently of beta(1) integrin.”. J. Biol. Chem.. 275 (8): 5779—84. PMID 10681566. doi:10.1074/jbc.275.8.5779.
- Foehr ED; Tatavos A; Tanabe E; et al. (2000). „Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors.”. FASEB J.. 14 (7): 973—81. PMID 10783152.
- Weiner HL; Huang H; Zagzag D; et al. (2001). „Consistent and selective expression of the discoidin domain receptor-1 tyrosine kinase in human brain tumors.”. Neurosurgery. 47 (6): 1400—9. PMID 11126911. doi:10.1097/00006123-200012000-00028.
- Mohan RR, Mohan RR, Wilson SE (2001). „Discoidin domain receptor (DDR) 1 and 2: collagen-activated tyrosine kinase receptors in the cornea.”. Exp. Eye Res.. 72 (1): 87—92. PMID 11133186. doi:10.1006/exer.2000.0932.
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