FUT4

Fukoziltransferaza 4 (alfa (1,3) fukoziltransferaza, mijeloid-specifična
Identifikatori
SimbolFUT4
Alt. simboliCD15, FCT3A, ELFT, SSEA-1, LeX
Entrez2526
HUGO4015
OMIM104230
RefSeqNM_002033
UniProtP22083
Ostali podaci
EC broj2.4.1.152
LokusHromozom 11 q21

Fukoziltransferaza 4 (alfa (1,3) fukoziltransferaza, mijeloid-specifična, takođe poznata kao FUT4, je enzim koji je kod ljudi kodiran genom FUT4.[1][2][3]

Funkcija

Proizvod ovog gena prenosi fukozu u polisaharide N-acetilaktozamina da bi se stvorile fukozilovane strukture ugljenih hidrata. On katalizuje sintezu nesijalilovanog antigena, Luis x (CD15).[4][5]

Reference

  1. ^ Goelz SE, Hession C, Goff D, Griffiths B, Tizard R, Newman B, Chi-Rosso G, Lobb R (децембар 1990). „ELFT: a gene that directs the expression of an ELAM-1 ligand”. Cell. 63 (6): 1349—56. PMID 1702034. S2CID 905332. doi:10.1016/0092-8674(90)90430-M. 
  2. ^ Couillin P, Mollicone R, Grisard MC, Gibaud A, Ravisé N, Feingold J, Oriol R (1991). „Chromosome 11q localization of one of the three expected genes for the human alpha-3-fucosyltransferases, by somatic hybridization”. Cytogenet. Cell Genet.. 56 (2): 108—11. PMID 1672847. doi:10.1159/000133061. 
  3. ^ Reguigne I, James MR, Richard CW, Mollicone R, Seawright A, Lowe JB, Oriol R, Couillin P (1994). „The gene encoding myeloid alpha-3-fucosyl-transferase (FUT4) is located between D1 1S388 and D11S919 on 11q21”. Cytogenet. Cell Genet.. 66 (2): 104—6. PMID 8287679. doi:10.1159/000133677. 
  4. ^ „Entrez Gene: FUT4”. 
  5. ^ Nakayama F, Nishihara S, Iwasaki H, Kudo T, Okubo R, Kaneko M, Nakamura M, Karube M, Sasaki K, Narimatsu H (мај 2001). „CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV”. J. Biol. Chem.. 276 (19): 16100—6. PMID 11278338. doi:10.1074/jbc.M007272200 Слободан приступ. 

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