Sirtuin

Sir2 familija
Kristalografska struktura kvasca sir2 (prikaz u duginim bojama, N-terminus = plavo, C-terminus = crveno) u kompleksu sa ADP (prostorno-popunjavajući model, ugljenik = bela, kiseonik = crvena, azot = plava, fosfor = narandžasta) i histonski H4 peptid (magenta) koji sadrži acilirani lizinski ostatak (prikazano kao sfere).[1]
Identifikatori
SimbolSIR2
PfamPF02146
Pfam klanCL0085
InterProIPR003000
PROSITEPS50305
SCOP1j8f
SUPERFAMILY1j8f

Sirtuini su familija signalnih proteina uključenih u metaboličku regulaciju.[2][3] Oni su drevnog porekla u evoluciji životinja i izgleda da poseduju visoko očuvanu strukturu u svim kraljevstvima života.[2] Hemijski, sirtuini su klasa proteina koji poseduju aktivnost mono-ADP-riboziltransferaze ili wikt:deacylasedeacilaze, uključujući aktivnost deacetilaze, desukcinilaze, demalonilaze, demiristoilaze i depalmitoilaze.[4][5][6] Naziv Sir2 potiče od gena kvasca „tiha regulacija informacija o tipu parenja 2“ ('silent mating-type information regulation 2'),[7] gena odgovornog za ćelijsku regulaciju u kvascu.

Reference

  1. ^ PDB: 1szd​; Zhao K, Harshaw R, Chai X, Marmorstein R (јун 2004). „Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases”. Proceedings of the National Academy of Sciences of the United States of America. 101 (23): 8563—8. Bibcode:2004PNAS..101.8563Z. PMC 423234 Слободан приступ. PMID 15150415. doi:10.1073/pnas.0401057101 Слободан приступ. 
  2. ^ а б Ye, X; Li, M; Hou, T; Gao, T; Zhu, WG; Yang, Y (3. 1. 2017). „Sirtuins in glucose and lipid metabolism.”. Oncotarget (Review). 8 (1): 1845—1859. PMC 5352102 Слободан приступ. PMID 27659520. doi:10.18632/oncotarget.12157. 
  3. ^ Yamamoto H, Schoonjans K, Auwerx J (август 2007). „Sirtuin functions in health and disease”. Molecular Endocrinology. 21 (8): 1745—55. PMID 17456799. doi:10.1210/me.2007-0079 Слободан приступ. 
  4. ^ Du J, Zhou Y, Su X, Yu JJ, Khan S, Jiang H, Kim J, Woo J, Kim JH, Choi BH, He B, Chen W, Zhang S, Cerione RA, Auwerx J, Hao Q, Lin H (новембар 2011). „Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase”. Science. 334 (6057): 806—9. Bibcode:2011Sci...334..806D. PMC 3217313 Слободан приступ. PMID 22076378. doi:10.1126/science.1207861. 
  5. ^ Jiang H, Khan S, Wang Y, Charron G, He B, Sebastian C, Du J, Kim R, Ge E, Mostoslavsky R, Hang HC, Hao Q, Lin H (април 2013). „SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine”. Nature. 496 (7443): 110—3. Bibcode:2013Natur.496..110J. PMC 3635073 Слободан приступ. PMID 23552949. doi:10.1038/nature12038. 
  6. ^ Rack JG, Morra R, Barkauskaite E, Kraehenbuehl R, Ariza A, Qu Y, Ortmayer M, Leidecker O, Cameron DR, Matic I, Peleg AY, Leys D, Traven A, Ahel I (јул 2015). „Identification of a Class of Protein ADP-Ribosylating Sirtuins in Microbial Pathogens”. Molecular Cell. 59 (2): 309—20. PMC 4518038 Слободан приступ. PMID 26166706. doi:10.1016/j.molcel.2015.06.013. 
  7. ^ EntrezGene 23410

Spoljašnje veze

  • Sirtuins на US National Library of Medicine Medical Subject Headings (MeSH)

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