INFORMASILENGKAP.COM

FUT9
Identifikatori
Alijasi	FUT9
Spoljašnji ID	OMIM: 606865 MGI: 1330859 HomoloGene: 4800 GeneCards: FUT9
EC number	2.4.1.152
Genska lokacija (miš)
Hr.	Chromosome 4 (mouse)
Kraj	25,800,244 bp
Obrazac RNK izražavanja
	More reference expression data
Genska ontologija
Molecular function	• glycosyltransferase activity; • alpha-(1->3)-fucosyltransferase activity; • fucosyltransferase activity; • transferase activity;
Cellular component	• саставни део мембране; • Голџијев апарат; • Golgi cisterna membrane; • мембрана; • Golgi membrane;
Biological process	• L-fucose catabolic process; • fucosylation; • ментални развој; • GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation; • Метаболизам угљених хидрата;
	Sources:Amigo / QuickGO
Ortolozi
	10690
	14348
	ENSG00000172461
	ENSMUSG00000055373
	Q9Y231
	O88819
	NM_006581
	NM_010243
	NP_006572
	NP_034373
	Wikidata
View/Edit Human	View/Edit Mouse

Fukoziltransferaza 9 je enzim koji je kod ljudi kodiran genom FUT9.^[4]^[5]^[6]

FUT9 je jedna od nekoliko alfa-3-fukoziltransferaza koje mogu katalizovati poslednji korak u biosintezi Luisovog antigena, dodavanje fukoze prekurzorskim polisaharidima. FUT9 sintetiše LeX oligosaharid (CD15), koji se izražava u pupoljcima organa koji napreduju u mezenhima tokom ljudske embriogeneze.^[6]

Reference

^ ^а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000055373 - Ensembl, May 2017
^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kaneko M, Kudo T, Iwasaki H, Ikehara Y, Nishihara S, Nakagawa S, Sasaki K, Shiina T, Inoko H, Saitou N, Narimatsu H (јул 1999). „Alpha1,3-fucosyltransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX”. FEBS Lett. 452 (3): 237—42. PMID 10386598. S2CID 21861521. doi:10.1016/S0014-5793(99)00640-7 .
^ Kaneko M, Kudo T, Iwasaki H, Shiina T, Inoko H, Kozaki T, Saitou N, Narimatsu H (јануар 2000). „Assignment of the human alpha 1,3-fucosyltransferase IX gene (FUT9) to chromosome band 6q16 by in situ hybridization”. Cytogenet Cell Genet. 86 (3–4): 329—30. PMID 10575236. S2CID 85080516. doi:10.1159/000015329.
^ ^а ^б „Entrez Gene: FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase)”.

Literatura

Bonaldo MF, Lennon G, Soares MB (1997). „Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Res.. 6 (9): 791—806. PMID 8889548. doi:10.1101/gr.6.9.791 .
Nishihara S, Iwasaki H, Kaneko M, et al. (2000). „Alpha1,3-fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four alpha1,3FUT members preferentially fucosylate the inner GlcNAc residue”. FEBS Lett.. 462 (3): 289—94. PMID 10622713. S2CID 37842289. doi:10.1016/S0014-5793(99)01549-5 .
Cailleau-Thomas A, Coullin P, Candelier JJ, et al. (2000). „FUT4 and FUT9 genes are expressed early in human embryogenesis”. Glycobiology. 10 (8): 789—802. PMID 10929005. doi:10.1093/glycob/10.8.789 .
Nakayama F, Nishihara S, Iwasaki H, et al. (2001). „CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV”. J. Biol. Chem.. 276 (19): 16100—6. PMID 11278338. doi:10.1074/jbc.M007272200.
Roos C, Kolmer M, Mattila P, Renkonen R (2002). „Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism”. J. Biol. Chem.. 277 (5): 3168—75. PMID 11698403. doi:10.1074/jbc.M107927200 .
Toivonen S, Nishihara S, Narimatsu H, et al. (2003). „Fuc-TIX: a versatile alpha1,3-fucosyltransferase with a distinct acceptor- and site-specificity profile”. Glycobiology. 12 (6): 361—8. PMID 12107078. doi:10.1093/glycob/12.6.361 .
Li H, Kong Y, Yan B (2003). „[Regulation by ovarian hormones of alpha 1,3-fucosyltransferase gene (FUT9) expression in human endometrium]”. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. 34 (6): 775—9. PMID 12417923.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899—903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
Nishihara S, Iwasaki H, Nakajima K, et al. (2004). „Alpha1,3-fucosyltransferase IX (Fut9) determines Lewis X expression in brain”. Glycobiology. 13 (6): 445—55. PMID 12626397. doi:10.1093/glycob/cwg048.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). „The DNA sequence and analysis of human chromosome 6”. Nature. 425 (6960): 805—11. Bibcode:2003Natur.425..805M. PMID 14574404. doi:10.1038/nature02055 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res.. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Bogoevska V, Horst A, Klampe B, et al. (2006). „CEACAM1, an adhesion molecule of human granulocytes, is fucosylated by fucosyltransferase IX and interacts with DC-SIGN of dendritic cells via Lewis x residues”. Glycobiology. 16 (3): 197—209. PMID 16282604. doi:10.1093/glycob/cwj057 .

[refGRCm38Ensembl-1] а ^б ^в GRCm38: Ensembl release 89: ENSMUSG00000055373 - Ensembl, May 2017

[2] „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10386598-4] Kaneko M, Kudo T, Iwasaki H, Ikehara Y, Nishihara S, Nakagawa S, Sasaki K, Shiina T, Inoko H, Saitou N, Narimatsu H (јул 1999). „Alpha1,3-fucosyltransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX”. FEBS Lett. 452 (3): 237—42. PMID 10386598. S2CID 21861521. doi:10.1016/S0014-5793(99)00640-7 .

[pmid10575236-5] Kaneko M, Kudo T, Iwasaki H, Shiina T, Inoko H, Kozaki T, Saitou N, Narimatsu H (јануар 2000). „Assignment of the human alpha 1,3-fucosyltransferase IX gene (FUT9) to chromosome band 6q16 by in situ hybridization”. Cytogenet Cell Genet. 86 (3–4): 329—30. PMID 10575236. S2CID 85080516. doi:10.1159/000015329.

[entrez-6] а ^б „Entrez Gene: FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase)”.

[1]

[2]

[3]

[4]

[5]

[6]

FUT9

Reference

Literatura

Content Disclaimer