Klatrin je protein koji ima centralnu ulogu u formiranju vezikula. Barbara Pears je prva izolovala i imenovala klatrin 1975.[1] On formira strukturu triskelionskog oblika koja se sastoji od tri klatrinska teška lanca i tri laka lanca. Kad se ove strukture slože nastaje polihedralna rešetka koja okružuje vezikulu. Pokrivajući proteini poput klatrina se koriste za formiranje malih vezikula kojima se molekuli mogu bezbedno trasportovati između ćelija. Endocitoza i egzocitoza vezikula omogućava ćelijama da razmenjuju nutrijente, da unose signalne receptore, da posreduju imunski respons nakon testiranja ekstracelularnog sveta, i uklanjaju ćelijski ostatke nakon zapaljenja tkiva. Povremeno ovaj mehanizam takođe služi kao način uklanjanja patogena ili toksina.
Ford MG, Mills IG, Peter BJ, Vallis Y, Praefcke GJ, Evans PR, McMahon HT (2002). „Curvature of clathrin-coated pits driven by epsin”. Nature. 419 (6905): 361—6. PMID12353027. doi:10.1038/nature01020.
Pérez-Gómez J, Moore I (2007). „Plant endocytosis: it is clathrin after all”. Current Biology : CB. 17 (6): R217—9. PMID17371763. doi:10.1016/j.cub.2007.01.045. (Review on involvement of clathrin in plant endocytosis - proven recently)
Knuehl C, Chen CY, Manalo V, Hwang PK, Ota N, Brodsky FM (2006). „Novel binding sites on clathrin and adaptors regulate distinct aspects of coat assembly”. Traffic (Copenhagen, Denmark). 7 (12): 1688—700. PMID17052248. doi:10.1111/j.1600-0854.2006.00499.x.
Edeling MA, Smith C, Owen D (2006). „Life of a clathrin coat: insights from clathrin and AP structures”. Nature Reviews Molecular Cell Biology. 7 (1): 32—44. PMID16493411. doi:10.1038/nrm1786.
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.
. PMID 1063406. doi:10.1073/pnas.73.4.1255.
