Metirozin

Metirosin
Klinički podaci
Prodajno imeDemser
Drugs.comPotrošačka informacije o leku
Identifikatori
CAS broj672-87-7 Зелена квачицаДа
ATC kodC02KB01 (WHO)
PubChemCID 10123
DrugBankDB00765 Зелена квачицаДа
ChemSpider390103 Зелена квачицаДа
UNIIDOQ0J0TPF7 Зелена квачицаДа
KEGGD00762 Зелена квачицаДа
ChEMBLCHEMBL1200862 Зелена квачицаДа

Metirozin (α-Metiltirozin, Metirozin, AMPT) je antihipertenzivni lek. On inhibira enzim tirozinska hidroksilaza i, stoga sintezu kateholamina. Posledica toga je snižavanje nivoa kateholamina dopamina, adrenalina i noradrenalina u telu.

Clinical use

Metirozin je korišten u tretmanu feohromocitoma.[1]

On se relativno retko koristi kao lek i prvenstveno nalazi primenu u naučnim istraživanjima čiji je cilj utvrđivanje uticaja iscrpljivanja kateholamina na ponašanje.[2]

Reference

  1. ^ Green KN, Larsson SK, Beevers DG, Bevan PG, Hayes B (1982). „Alpha-methyltyrosine in the management of phaeochromocytoma”. Thorax. 37 (8): 632—3. PMC 459390 Слободан приступ. PMID 7179194. doi:10.1136/thx.37.8.632. 
  2. ^ O'Leary OF, Bechtholt AJ, Crowley JJ, Hill TE, Page ME, Lucki I. O'Leary, O. F.; Bechtholt, A. J.; Crowley, J. J.; Hill, T. E.; Page, M. E.; Lucki, I. (јун 2007). „Depletion of serotonin and catecholamines block the acute behavioral response to different classes of antidepressant drugs in the mouse tail suspension test”. Psychopharmacology (Berlin). 192 (3): 357—371. PMID 17318507. doi:10.1007/s00213-007-0728-9. 

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