Gvanfacin

Gvanfacin
Klinički podaci
Prodajno imeTenex, Intuniv
Drugs.comMonografija
MedlinePlusa601059
Kategorija trudnoće
  • B
Način primeneoralno, intravenozno
Pravni status
Pravni status
  • ℞ (Prescription only)
Identifikatori
CAS broj29110-47-2 Зелена квачицаДа
ATC kodC02AC02 (WHO)
PubChemCID 3519
IUPHAR/BPS522
DrugBankDB01018 Зелена квачицаДа
ChemSpider3399 Зелена квачицаДа
UNII30OMY4G3MK Зелена квачицаДа
KEGGD08031 Зелена квачицаДа
ChEMBLCHEMBL862 Зелена квачицаДа

Guanfacin (Teneks, Intuniv) je simpatolitik. On je selektivni agonist α2A receptora. Ti receptori su koncentrisani u prefrontalnom korteksu, te guanfacin potencijalno može da poboljša sposobnost pažnje putem modulisanja postsinaptičkih α2A receptora.[1] Guanfacin snižava sistolni i dijastolni krvni pritisak putem aktivacije α-2a norepinefrinskih autoreceptora centralnog nervnog sistema, što dovodi do redukcije perifernog simpatetičkog odliva i stoga do redukcije perifernog simpatetičkog tona.[2] Njegove nuspojave su zavisne od doze. Pri dozama do 2 mg efekat suvih usta se praktično ne javlja.[3]

Reference

  1. ^ Kolar, Dusan; Keller, Amanda; Golfinopoulos, Maria; Cumyn, Lucy; Syer, Cassidy & Hechtman, Lily (2008), „Treatment of adults with attention-deficit/hyperactivity disorder”, Neuropsychiatric Disease and Treatment, 4 (2): 389—403, PMC 2518387 Слободан приступ, PMID 18728745 .
  2. ^ Van Zwieten, P.; Thoolen, M. & Timmermans, P. (1983), „The pharmacology of centrally acting antihypertensive drugs”, British Journal of Clinical Pharmacology, 15 (Suppl 4): 455S—462S, PMC 1427667 Слободан приступ .
  3. ^ Jerie, P. (1980), „Clinical experience with guanfacine in long-term treatment of hypertension: Part II: adverse reactions to guanfacine”, British Journal of Clinical Pharmacology, 10 (Suppl 1): 157S—164S, PMC 1430125 Слободан приступ, PMID 6994770 .

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