Setiptilin

Setiptilin
Klinički podaci
Drugs.comInternacionalno ime leka
Način primeneOralno
Pravni status
Pravni status
  • Rx-only
Identifikatori
CAS broj57262-94-9 Зелена квачицаДа
ATC kodnone
PubChemCID 5205
ChemSpider5016 Зелена квачицаДа
UNII7L38105Z6E Зелена квачицаДа
KEGGD08511 Зелена квачицаДа

Setiptilin (Tecipul, teciptilin) je tetraciklični antidepresiv (TeCA) koji deluje kao noradrenergički i specifični serotonergički antidepresiv (NaSSA). Kompanija Močida ga je plasirala na tržište 1989. godine kao lek za tretman depresije u Japanu.[1][2]

Hemija

Setiptilin sadrži tetracikličnu strukturu. On je analog mijanserina i mirtazapina. Setiptilin je delta(13b,4a),4a-karba-mianserin, dok je mirtazapin 6-aza-mianserin.

Farmakologija

Setiptilin deluje kao inhibitor preuzimanja norepinefrina,[3] antagonist α2-adrenergičkog receptora,[4] i antagonist serotoninskih receptora,[5] 5-HT2A, 5-HT2C, i/ili 5-HT3, kao i inverzni agonist H1 receptor.[3]

Reference

  1. ^ Buschmann, H.; Torrens, A.; Vela, J. M. (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. 1. Wiley VCH. стр. 248. ISBN 978-3-527-31058-6. [мртва веза]
  2. ^ Swiss Pharmaceutical Society, ур. (2000). Index Nominum 2000: International Drug Directory. Medpharm Scientific Publishers. стр. 942. ISBN 978-3-88763-075-1. 
  3. ^ а б Niho, T.; Ito, C.; Shibutani, Y.; Hashizume, H.; Yamaguchi, K. (1986). „Pharmacological Properties of MO-8282, a Novel Antidepressant”. Nihon yakurigaku zasshi. Folia Pharmacologica Japonica. 88 (4): 309—320. PMID 3792961. 
  4. ^ Mizota, M.; Oikawa, Y.; Nakayama, K.; Mizuguchi, K.; Takarada, T.; Kojima, M.; Kanehiro, H.; Funato, H.; Kayamoto, M. (1986). „Pharmacological Studies of MO-8282, a New Antidepressant”. Nihon yakurigaku zasshi. Folia Pharmacologica Japonica. 88 (6): 457—466. PMID 2881854. 
  5. ^ Przegaliński, E.; Baran, L.; Siwanowicz, J.; Rawłów, A. (1986). „The Lack of Antidepressant Properties and a Potent Central Antiserotonin Activity of Org 8282”. Polish Journal of Pharmacology and Pharmacy. 38 (4): 377—384. PMID 3774630. 

Literatura

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