Citikolin

Citikolin
Klinički podaci
Drugs.comInternacionalno ime leka
Identifikatori
CAS broj987-78-0 Зелена квачицаДа
ATC kodN06BX06 (WHO)
PubChemCID 13805
ChemSpider16736209 Зелена квачицаДа
UNII536BQ2JVC7 Зелена квачицаДа
KEGGD00057 Зелена квачицаДа
ChEMBLCHEMBL1618340 Зелена квачицаДа
SinonimiCytidine diphosphate choline

Citikolin (citidin difosfat-holin, CDP-holin, citidin 5'-difosfoholin) je psihostimulans/nutropik. On je intermedijar u generaciji fosfatidilholina iz holina.

Ispitivanja sugerišu da CDP-holin suplementi povećavaju gustine dopaminskog receptora,[1] i da pomažu u sprečavanju gubljenja memorije uzrokovanog lošim uslovima životne sredine.[2] Preliminarna ispitivanja su utvrdila da citikolinski suplementi pomažu u poboljšanju fokusa i mentalne energije, te da potencijalno mogu da budu korisni u tretmanu deficita koncentracije.[3][4] Citikolin isto tako povišava nivo ACTH-a nezavisno od nivoa CRH.[5]

Reference

  1. ^ Giménez R, Raïch J, Aguilar J (1991). „Changes in brain striatum dopamine and acetylcholine receptors induced by chronic CDP-choline treatment of aging mice”. British Journal of Pharmacology. 104 (3): 575—8. PMC 1908237 Слободан приступ. PMID 1839138. 
  2. ^ Teather LA, Wurtman RJ (2005). „Dietary CDP-choline supplementation prevents memory impairment caused by impoverished environmental conditions in rats”. Learning & Memory. 12 (1): 39—43. PMC 548494 Слободан приступ. PMID 15647594. doi:10.1101/lm.83905. 
  3. ^ „Supplement naturally boosts ageing brain power”. Sydney Morning Herald. 25. 02. 2008. Приступљено 28. 07. 2009. 
  4. ^ Silveri MM; Dikan J; Ross AJ; et al. (2008). „Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy”. NMR in Biomedicine. 21 (10): 1066—75. PMID 18816480. doi:10.1002/nbm.1281. 
  5. ^ Cavun S, Savci V (2004). „CDP-choline increases plasma ACTH and potentiates the stimulated release of GH, TSH and LH: the cholinergic involvement”. Fundamental & Clinical Pharmacology. 18 (5): 513—23. PMID 15482372. doi:10.1111/j.1472-8206.2004.00272.x. 

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