Holin
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| Nazivi | |
|---|---|
| IUPAC naziv
2-Hidroksi-N,N,N-trimetiletanaminijum
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| Drugi nazivi
Bilinurin, (2-Hidroksietil)trimetilamonijum
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| Identifikacija | |
3D model (Jmol)
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| Bajlštajn | 1736748 |
| ChEBI | |
| ChemSpider | |
| DrugBank | |
| ECHA InfoCard | 100.000.487 |
| EC broj | 200–655–4 |
| E-brojevi | E1001 (dodatne hemikalije) |
| Gmelin Referenca | 324597 |
| KEGG[1] | |
| UNII | |
| |
| Svojstva | |
| C5H14NO | |
| Molarna masa | 104,17080 |
| Gustina | 1,09 g/ml |
| Tačka ključanja | 305 °C (581 °F; 578 K) |
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa). | |
 verifikuj (šta je  ?)
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| Reference infokutije | |
Holin je u vodi rastvoran esencijalni nutrijent.[4][5][6][7] On se obično svrstava u B-kompleks vitamina. Holin se normalno javlja u obliku raznih kvaternarnih amonijum soli koje sadrže N,N,N-trimetiletanolamonijum katjon.
Katjon holina se javlja kao čeona grupa fosfatidilholina i sfingomijelina, dve klase fosfolipida koje su široko rasprostranjene u ćelijskim membranama. Holin je prekursorni molekul za neurotransmiter acetilholin koji ima veliki broj funkcija, kao što su memorija i kontrola mišića.
Holin se mora uneti putem hrane da bi telo ostalo zdravo.[8] On se koristi u sintezi gradivnih komponenti ćelijskih membrana.[9]
Reference
- ^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.
- ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
- ^ Jane Higdon, "Choline", Micronutrient Information Center, Linus Pauling Institute, Oregon State University
- ^ Zeisel SH, da Costa KA (2009). „Choline: an essential nutrient for public health”. Nutrition Reviews. 67 (11): 615—23. PMC 2782876
. PMID 19906248. doi:10.1111/j.1753-4887.2009.00246.x.
- ^ "Choline" (An interview with Steven Zeisel, Editor-in-Chief of the Journal of Nutritional Biochemistry), Radio National Health Report with Norman Swan, Monday 17 April 2000
- ^ "[1]" Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (1998), Institute of Medicine.
- ^ Choline (at Linus Paulin Inst)
- ^ AJCN 92 n5: 1113-1119 (Nov 2010)
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