Muskarin

Muskarin
Chemical structure of muscarine
Nazivi
IUPAC naziv
2,5-anhydro-1,4,6-trideoxy-6-(trimethylammonio)-D-ribo-hexitol
Drugi nazivi
L-(+)-muscarine, muscarin, (2S,4R,5S)-(4-hydroxy-5-methyl-tetrahydrofuran-2-ylmethyl)-trimethyl-ammonium
Identifikacija
3D model (Jmol)
ECHA InfoCard 100.005.541
  • O[C@@H]1C[C@@H](C[N+](C)(C)C)O[C@H]1C
Svojstva
C9H20NO2+
Molarna masa 174,26 g/mol
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
Reference infokutije
Amanita muscaria

Muskarin, L-(+)-muskarin, je prirodni proizvod nađen u pojedinim pečurkama, posebno u vrstama Inocybe i Clitocybe, kao i u smrtonosnoj C. dealbata. Ovo jedinjenje je prvi put izolovano iz Amanita muscaria 1869. To je bila prva parasimpatomimetska supstanca ikad studirana. Ona uzrokuje snažnu aktivaciju perifernog parasimpatetičkog nervnog sistema što može da dovede do konvulzija i smrti.

Muscarine je kvaternarni amin, iz kog razloga se u manjoj meri apsorbuje uz gastrointestinalnog trakta u poređenju sa tercijarnim aminima. Ovo jedinjenje ne prelazi krvno-moždanu barijeru.[1]

Muskarin oponaša dejstvo neurotransmitera acetilholina na muskarinskim acetilholinskim receptorima. Ti receptorima je data ime po muskarinu.

Vidi još

Reference

  1. ^ Pappano Achilles J (2006). „Chapter 7. Cholinoceptor-Activating & Cholinesterase-Inhibiting Drugs”. Ур.: Katzung, Bertram G.. Basic and clinical pharmacology. New York: McGraw-Hill Medical Publishing Division. ISBN 0-07-145153-6. Архивирано из оригинала 10. 09. 2009. г.. 

Literatura

Spoljašnje veze

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