Cdc6

Cdc6
Kristalna struktura CDC6p iz P. aerophilum.[1]
Identifikatori
SimbolCdc6
Alt. simboliYJL194W
Entrez853244
PDB1FNN
UniProtP09119

Cdc6 (engl. cell division cycle 6) je eukariotski protein koji je detaljno izučen kod pekarskog kvasca Saccharomyces cerevisiae. On je esencijalni regulator replikacije DNK i ima važnu ulogu u aktivaciji i održavanju kontrolnog mehanizma tokom ćelijskog ciklusa kojim se koordinira S faza u mitoza. On je deo prereplikacionog kompleksa (pre-RC) i neophodan je za postavljanje proteina mini hromozomskog održavanja (MCM) na DNK, što je ključni korak u inicijaciji DNK sinteze. Osim toga, on je član familije AAA+ ATPaza i u znatnoj meri je vezan za Orc1p.

Reference

  1. ^ PDB: 1FNN​Liu J, Smith CL, DeRyckere D, DeAngelis K, Martin GS, Berger JM (2000). „Structure and function of Cdc6/Cdc18: implications for origin recognition and checkpoint control”. Mol. Cell. 6 (3): 637—48. PMID 11030343. doi:10.1016/S1097-2765(00)00062-9. 

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