POLD3

POLD3
Available structures
PDBPretraga ortologa: PDBe RCSB
Identifikatori
AlijasiPOLD3
Spoljašnji IDOMIM: 611415 MGI: 1915217 HomoloGene: 38202 GeneCards: POLD3
Obrazac RNK izražavanja
More reference expression data
Ortolozi
VrsteČovekMiš
Entrez

10714

67967

Ensembl

ENSG00000077514

ENSMUSG00000030726

UniProt

Q15054

Q9EQ28

RefSeq (mRNA)

NM_006591
NM_001363597

NM_133692
NM_001368380

RefSeq (protein)

NP_006582
NP_001350526

NP_598453
NP_001355309

Location (UCSC)n/aChr 7: 99.73 – 99.77 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Delta podjedinica 3 DNK polimeraze je enzim koji je kod ljudi kodiran POLD3 genom.[4][5] Ona je komponenta kompleksa DNK polimeraze delta.

Interakcije

POLD3 formira interakcije sa PCNA.[6][7]

Reference

  1. ^ а б в GRCm38: Ensembl release 89: ENSMUSG00000030726 - Ensembl, May 2017
  2. ^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  3. ^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  4. ^ Hughes P, Tratner I, Ducoux M, Piard K, Baldacci G (1999). „Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts”. Nucleic Acids Res. 27 (10): 2108—14. PMC 148430 Slobodan pristup. PMID 10219083. doi:10.1093/nar/27.10.2108. 
  5. ^ „Entrez Gene: POLD3 polymerase (DNA-directed), delta 3, accessory subunit”. 
  6. ^ Ducoux M, Urbach S, Baldacci G, Hübscher U, Koundrioukoff S, Christensen J, Hughes P (2001). „Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta”. J. Biol. Chem. 276 (52): 49258—66. PMID 11595739. doi:10.1074/jbc.M106990200. 
  7. ^ Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. 277 (43): 40362—7. PMID 12171929. doi:10.1074/jbc.M206194200. 

Literatura

  • Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1995). „Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1”. DNA Res. 1 (1): 27—35. PMID 7584026. doi:10.1093/dnares/1.1.27. 
  • Zeng XR, Jiang Y, Zhang SJ, Hao H, Lee MY (1994). „DNA polymerase delta is involved in the cellular response to UV damage in human cells”. J. Biol. Chem. 269 (19): 13748—51. PMID 7910606. 
  • Longley MJ, Pierce AJ, Modrich P (1997). „DNA polymerase delta is required for human mismatch repair in vitro”. J. Biol. Chem. 272 (16): 10917—21. PMID 9099749. doi:10.1074/jbc.272.16.10917. 
  • Mo J, Liu L, Leon A, Mazloum N, Lee MY (2000). „Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA”. Biochemistry. 39 (24): 7245—54. PMID 10852724. doi:10.1021/bi0000871. 
  • Ducoux M, Urbach S, Baldacci G, Hübscher U, Koundrioukoff S, Christensen J, Hughes P (2002). „Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta”. J. Biol. Chem. 276 (52): 49258—66. PMID 11595739. doi:10.1074/jbc.M106990200. 
  • Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. 277 (43): 40362—7. PMID 12171929. doi:10.1074/jbc.M206194200. 
  • Pohler JR, Otterlei M, Warbrick E (2006). „An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit”. BMC Mol. Biol. 6: 17. PMC 1187890 Slobodan pristup. PMID 16000169. doi:10.1186/1471-2199-6-17. 
  • Takemura M, Yoshida S, Akiyama T, Kitagawa M, Yamada Y (2006). „Role of the second-largest subunit of DNA polymerase alpha in the interaction between the catalytic subunit and hyperphosphorylated retinoblastoma protein in late S phase”. Biochim. Biophys. Acta. 1764 (9): 1447—53. PMID 16935576. doi:10.1016/j.bbapap.2006.06.015. 
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). „Global, in vivo, and site-specific phosphorylation dynamics in signaling networks”. Cell. 127 (3): 635—48. PMID 17081983. doi:10.1016/j.cell.2006.09.026. 
  • Masuda Y, Suzuki M, Piao J, Gu Y, Tsurimoto T, Kamiya K (2007). „Dynamics of human replication factors in the elongation phase of DNA replication”. Nucleic Acids Res. 35 (20): 6904—16. PMC 2175312 Slobodan pristup. PMID 17932049. doi:10.1093/nar/gkm822. 

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