RNASEH1
| Ribonukleaza H1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
 | |||||||||||
| Доступне структуре | |||||||||||
| 2QK9, 2QKB, 2QKK, 3BSU | |||||||||||
| Идентификатори | |||||||||||
| Симболи | RNASEH1; H1RNA; RNH1 | ||||||||||
| Вањски ИД | OMIM: 604123 MGI: 1335073 HomoloGene: 2202 GeneCards: RNASEH1 Gene | ||||||||||
| ЕЦ број | 3.1.26.4 | ||||||||||
| |||||||||||
| Ортолози | |||||||||||
| Врста | Човек | Миш | |||||||||
| Ентрез | 246243 | 19819 | |||||||||
| Eнсембл | ENSG00000171865 | ENSMUSG00000020630 | |||||||||
| UниПрот | O60930 | E9QLN8 | |||||||||
| Реф. Секв. (иРНК) | NM_002936 | NM_011275 | |||||||||
| Реф. Секв. (протеин) | NP_002927 | NP_035405 | |||||||||
| Локација (УЦСЦ) |
Chr 2: 3.59 - 3.61 Mb |
Chr 12: 28.65 - 28.66 Mb | |||||||||
| ПубМед претрага | [1] | [2] | |||||||||
Рибонуклеазе Х1, такође позната као RNaza H1, је ензим, који је код људи кодиран RNASEH1 геном.[1][2][3]. RNaza H1 је неспецифична ендонуклеаза која катализује пресецање РНК хидролитицке механизмом.
Референце
- ^ „Entrez Gene: ribonuclease H1”.
- ^ ten Asbroek AL, van Groenigen M, Jakobs ME, Koevoets C, Janssen B, Baas F (јун 2002). „Ribonuclease H1 maps to chromosome 2 and has at least three pseudogene loci in the human genome”. Genomics. 79 (6): 818—23. PMID 12036296. doi:10.1006/geno.2002.6776.
- ^ Nowotny M, Gaidamakov SA, Ghirlando R, Cerritelli SM, Crouch RJ, Yang W (октобар 2007). „Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription”. Mol. Cell. 28 (2): 264—76. PMID 17964265. doi:10.1016/j.molcel.2007.08.015.
Литература
- Nowotny M; Cerritelli SM; Ghirlando R; et al. (2008). „Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD.”. EMBO J.. 27 (7): 1172—81. PMC 2323259
. PMID 18337749. doi:10.1038/emboj.2008.44. - Lima WF; Wu H; Nichols JG; et al. (2003). „Human RNase H1 uses one tryptophan and two lysines to position the enzyme at the 3'-DNA/5'-RNA terminus of the heteroduplex substrate.”. J. Biol. Chem.. 278 (50): 49860—7. PMID 14506260. doi:10.1074/jbc.M306543200.
- Lima WF; Rose JB; Nichols JG; et al. (2007). „The positional influence of the helical geometry of the heteroduplex substrate on human RNase H1 catalysis.”. Mol. Pharmacol.. 71 (1): 73—82. PMID 17028157. doi:10.1124/mol.106.025429.
- Lima WF; Nichols JG; Wu H; et al. (2004). „Structural requirements at the catalytic site of the heteroduplex substrate for human RNase H1 catalysis.”. J. Biol. Chem.. 279 (35): 36317—26. PMID 15205459. doi:10.1074/jbc.M405035200.
- Otsuki T; Ota T; Nishikawa T; et al. (2005). „Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”. DNA Res.. 12 (2): 117—26. PMID 16303743. doi:10.1093/dnares/12.2.117.
- Wu H, Lima WF, Crooke ST (1999). „Properties of cloned and expressed human RNase H1.”. J. Biol. Chem.. 274 (40): 28270—8. PMID 10497183. doi:10.1074/jbc.274.40.28270.
- Frank P, Braunshofer-Reiter C, Pöltl A, Holzmann K (1998). „Cloning, subcellular localization and functional expression of human RNase HII.”. Biol. Chem.. 379 (12): 1407—12. PMID 9894807. doi:10.1515/bchm.1998.379.12.1407.
- Wu H; Lima WF; Zhang H; et al. (2004). „Determination of the role of the human RNase H1 in the pharmacology of DNA-like antisense drugs.”. J. Biol. Chem.. 279 (17): 17181—9. PMID 14960586. doi:10.1074/jbc.M311683200.
- Hillier LW; Graves TA; Fulton RS; et al. (2005). „Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”. Nature. 434 (7034): 724—31. PMID 15815621. doi:10.1038/nature03466.
- Lima WF; Wu H; Nichols JG; et al. (2003). „Human RNase H1 activity is regulated by a unique redox switch formed between adjacent cysteines.”. J. Biol. Chem.. 278 (17): 14906—12. PMID 12473655. doi:10.1074/jbc.M211279200.
- ten Asbroek AL, van Groenigen M, Nooij M, Baas F (2002). „The involvement of human ribonucleases H1 and H2 in the variation of response of cells to antisense phosphorothioate oligonucleotides.”. Eur. J. Biochem.. 269 (2): 583—92. PMID 11856317. doi:10.1046/j.0014-2956.2001.02686.x.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res.. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Ota T; Suzuki Y; Nishikawa T; et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet.. 36 (1): 40—5. PMID 14702039. doi:10.1038/ng1285.
- Cerritelli SM, Crouch RJ (1998). „Cloning, expression, and mapping of ribonucleases H of human and mouse related to bacterial RNase HI.”. Genomics. 53 (3): 300—7. PMID 9799596. doi:10.1006/geno.1998.5497.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2002). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Cerritelli SM; Frolova EG; Feng C; et al. (2003). „Failure to produce mitochondrial DNA results in embryonic lethality in Rnaseh1 null mice.”. Mol. Cell. 11 (3): 807—15. PMID 12667461. doi:10.1016/S1097-2765(03)00088-1.
- Lima WF; Rose JB; Nichols JG; et al. (2007). „Human RNase H1 discriminates between subtle variations in the structure of the heteroduplex substrate.”. Mol. Pharmacol.. 71 (1): 83—91. PMID 17028158. doi:10.1124/mol.106.025015.
Content Disclaimer
Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.
- The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
- There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
- It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
- Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
- Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.