DnaN

Beta podjedinica DNK polimeraze III
Kristalografksa struktura dimerne beta podjednice DNK polimeraze iz E. coli.[1]
Identifikatori
Organizam Escherichia coli
(vrsta K-12 podvrsta MG1655)
Simbol dnaN
Entrez 948218
PDB 1MMI
RefSeq (Prot) NP_418156
UniProt P0A988
Other data
EC broj 2.7.7.7
Hromozom MG1655: 3.88 - 3.88 Mb

DnaN је ген који кодира ДНК стегу (такође познату као β клизећа стега) ДНК полимеразе III код прокариота[2][3]. β стега физички фиксира Пол III на ДНК ланац током репликације, чиме доприноси повећању процесивности[4].

Референце

  1. ^ PDB: 1MMI​; Oakley AJ, Prosselkov P, Wijffels G, Beck JL, Wilce MC, Dixon NE (2003). „Flexibility revealed by the 1.85 Å crystal structure of the beta sliding-clamp subunit of Escherichia coli DNA polymerase III”. Acta Crystallogr. D Biol. Crystallogr.. 59 (Pt 7): 1192—9. PMID 12832762. doi:10.1107/S0907444903009958. 
  2. ^ Ohmori H, Kimura M, Nagata T, Sakakibara Y (1984). „Structural analysis of the dnaA and dnaN genes of Escherichia coli”. Gene. 28 (2): 159—70. PMID 6234204. doi:10.1016/0378-1119(84)90253-1. 
  3. ^ Armengod ME, García-Sogo M, Lambíes E (1988). „Transcriptional organization of the dnaN and recF genes of Escherichia coli K-12”. J. Biol. Chem.. 263 (24): 12109—14. PMID 2841344. 
  4. ^ Stukenberg PT, Studwell-Vaughan PS, O'Donnell M (1991). „Mechanism of the sliding beta-clamp of DNA polymerase III holoenzyme”. J. Biol. Chem.. 266 (17): 11328—34. PMID 2040637. 

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