ORC4
| Комплекс препознавања места почетка, подјединица 4 | |||||||||||
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| Идентификатори | |||||||||||
| Симболи | ORC4; ORC4L; ORC4P | ||||||||||
| Вањски ИД | OMIM: 603056 MGI: 1347043 HomoloGene: 8059 GeneCards: ORC4 Gene | ||||||||||
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| Преглед РНК изражавања | |||||||||||
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| подаци | |||||||||||
| Ортолози | |||||||||||
| Врста | Човек | Миш | |||||||||
| Ентрез | 5000 | 26428 | |||||||||
| Eнсембл | ENSG00000115947 | ENSMUSG00000026761 | |||||||||
| UниПрот | O43929 | O88708 | |||||||||
| Реф. Секв. (иРНК) | NM_001190879 | NM_001177313 | |||||||||
| Реф. Секв. (протеин) | NP_001177808 | NP_001170784 | |||||||||
| Локација (УЦСЦ) |
Chr 2: 148.69 - 148.78 Mb |
Chr 2: 48.9 - 48.95 Mb | |||||||||
| ПубМед претрага | [1] | [2] | |||||||||
Комплекс препознавања места почетка 4 је протеин који је код људи кодиран ОРЦ4 (ORC4L) геном[1][2][3].
Комплекс препознавања места почетка (ORC) је високо конзервисани протеински комплекс са шест подјединица који је есенцијалан за иницијацију репликације ДНК код еукариотских ћелија. Истраживања на квасцу су показала да се ОРЦ специфично везује за место почетка репликације и да служи као платформа за конструкцију пререпликационог комплекса, који садржи додатне иницијациона факторе као што су Cdc6 и mcm протеини. Протеин кодиран овим геном је подјединица комплекса препознавања места почетка. Показано је да формира сржни комплекс са ORC2L, -3L, i -5L. Три алтернативно сплајсоване транскриптне варијанте кодирају исти протеин[3].
Интеракције
ОРЦ4 мође да формира интеракције са ORC1,[4] MCM6,[4] ORC2,[1][4][5][6] ORC5,[4][5][7] ORC3,[5][6][8] MCM2,[4] MCM4,[4] MCM3[4] i ORC6.[4]
Референце
- ^ а б Quintana DG; Hou Zh; Thome KC; Hendricks M; Saha P; Dutta A (1997). „Identification of HsORC4, a member of the human origin of replication recognition complex”. J Biol Chem. 272 (45): 28247—51. PMID 9353276. doi:10.1074/jbc.272.45.28247.
- ^ Eki T, Dean FB, Kohda A, Okumura K, Abe M, Murakami Y, Ishiai M, Satomoto K, Hurwitz J, O'Donnell M, Hanaoka F (1998). „Assignment of the homologue of the yeast origin recognition complex subunit ORC4 (ORC4L) to human chromosome band 2q22→q23 by in situ hybridization and somatic cell hybrid analysis”. Cytogenet Cell Genet. 81 (1): 89—90. PMID 9691185. doi:10.1159/000014997.
- ^ а б „Entrez Gene: ORC4L origin recognition complex, subunit 4-like (yeast)”.
- ^ а б в г д ђ е ж Kneissl, Margot; Pütter Vera; Szalay Aladar A; Grummt Friedrich (2003). „Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells”. J. Mol. Biol.. England. 327 (1): 111—28. ISSN 0022-2836. PMID 12614612. doi:10.1016/S0022-2836(03)00079-2.
- ^ а б в Dhar, S K; Delmolino L; Dutta A (2001). „Architecture of the human origin recognition complex”. J. Biol. Chem.. United States. 276 (31): 29067—71. ISSN 0021-9258. PMID 11395502. doi:10.1074/jbc.M103078200.
- ^ а б Vashee, S; Simancek P; Challberg M D; Kelly T J (2001). „Assembly of the human origin recognition complex”. J. Biol. Chem.. United States. 276 (28): 26666—73. ISSN 0021-9258. PMID 11323433. doi:10.1074/jbc.M102493200.
- ^ Quintana, D G; Thome K C; Hou Z H; Ligon A H; Morton C C; Dutta A (1998). „ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases”. J. Biol. Chem.. UNITED STATES. 273 (42): 27137—45. ISSN 0021-9258. PMID 9765232. doi:10.1074/jbc.273.42.27137.
- ^ Pinto, S; Quintana D G; Smith P; Mihalek R M; Hou Z H; Boynton S; Jones C J; Hendricks M; Velinzon K; Wohlschlegel J A; Austin R J; Lane W S; Tully T; Dutta A (1999). „latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant”. Neuron. UNITED STATES. 23 (1): 45—54. ISSN 0896-6273. PMID 10402192. doi:10.1016/S0896-6273(00)80752-7.
Литература
- Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.”. Gene. 138 (1–2): 171—4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
- Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K; et al. (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library”. Gene. 200 (1–2): 149—56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
- Tugal T; Zou-Yang XH; Gavin K; et al. (1999). „The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p”. J. Biol. Chem.. 273 (49): 32421—9. PMID 9829972. doi:10.1074/jbc.273.49.32421.
- Springer J, Kneissl M, Pütter V, Grummt F (1999). „Identification and characterization of MmORC4 and MmORC5, two subunits of the mouse origin of replication recognition complex”. Chromosoma. 108 (4): 243—9. PMID 10460412. doi:10.1007/s004120050374.
- Jiang W, McDonald D, Hope TJ, Hunter T (1999). „Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication”. EMBO J.. 18 (20): 5703—13. PMC 1171637
. PMID 10523313. doi:10.1093/emboj/18.20.5703. - Thome KC; Dhar SK; Quintana DG; et al. (2001). „Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins”. J. Biol. Chem.. 275 (45): 35233—41. PMID 10954718. doi:10.1074/jbc.M005765200.
- Vashee S, Simancek P, Challberg MD, Kelly TJ (2001). „Assembly of the human origin recognition complex”. J. Biol. Chem.. 276 (28): 26666—73. PMID 11323433. doi:10.1074/jbc.M102493200.
- Dhar SK, Delmolino L, Dutta A (2001). „Architecture of the human origin recognition complex”. J. Biol. Chem.. 276 (31): 29067—71. PMID 11395502. doi:10.1074/jbc.M103078200.
- Okuno Y; McNairn AJ; den Elzen N; et al. (2001). „Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycle”. EMBO J.. 20 (15): 4263—77. PMC 149150 . PMID 11483529. doi:10.1093/emboj/20.15.4263.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Kneissl M, Pütter V, Szalay AA, Grummt F (2003). „Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells”. J. Mol. Biol.. 327 (1): 111—28. PMID 12614612. doi:10.1016/S0022-2836(03)00079-2.
- Ota T; Suzuki Y; Nishikawa T; et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet.. 36 (1): 40—5. PMID 14702039. doi:10.1038/ng1285.
- Ramachandran N; Hainsworth E; Bhullar B; et al. (2004). „Self-assembling protein microarrays”. Science. 305 (5680): 86—90. PMID 15232106. doi:10.1126/science.1097639.
- Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res.. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Sibani S, Price GB, Zannis-Hadjopoulos M (2005). „Ku80 binds to human replication origins prior to the assembly of the ORC complex”. Biochemistry. 44 (21): 7885—96. PMID 15910003. doi:10.1021/bi047327n.
- Rual JF; Venkatesan K; Hao T; et al. (2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173—8. PMID 16189514. doi:10.1038/nature04209.
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