CBiPES

CBiPES
Klinički podaci
Drugs.comMonografija
Identifikatori
CAS broj856702-40-4 Зелена квачицаДа
ATC kodnone
PubChemCID 9864510
ChemSpider8040202 Зелена квачицаДа

CBiPES je lek koji se koristi u naučnim istraživanjima koji deluje kao selektivni pozitivni alosterični modulator za metabotropni glutamat receptor grupe II podtip mGluR2. On ima potencijalno antipsihotične efekte na životinjskim modelima i koristi se za istraživanje uloge mGluR2 receptora u šizofreniji i srodnim poremećajima.[1][2][3]

Osobine

CBiPES je organsko jedinjenje, koje sadrži 21 atom ugljenika i ima molekulsku masu od 377,459 Da.

Osobina Vrednost
Broj akceptora vodonika 4
Broj donora vodonika 0
Broj rotacionih veza 6
Particioni koeficijent[4] (ALogP) 3,1
Rastvorljivost[5] (logS, log(mol/L)) -6,0
Polarna površina[6] (PSA, Å2) 82,4

Reference

  1. ^ Johnson MP, Barda D, Britton TC, Emkey R, Hornback WJ, Jagdmann GE, et al. (април 2005). „Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s)”. Psychopharmacology. 179 (1): 271—83. PMID 15717213. S2CID 2699540. doi:10.1007/s00213-004-2099-9. 
  2. ^ Fell MJ, Katner JS, Johnson BG, Khilevich A, Schkeryantz JM, Perry KW, Svensson KA (март 2010). „Activation of metabotropic glutamate (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute ketamine challenge”. Neuropharmacology. 58 (3): 632—9. PMID 19951716. S2CID 7262560. doi:10.1016/j.neuropharm.2009.11.014. 
  3. ^ Sanger H, Hanna L, Colvin EM, Grubisha O, Ursu D, Heinz BA, et al. (март 2013). „Pharmacological profiling of native group II metabotropic glutamate receptors in primary cortical neuronal cultures using a FLIPR”. Neuropharmacology. 66: 264—73. PMID 22659090. S2CID 42448364. doi:10.1016/j.neuropharm.2012.05.023. 
  4. ^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o. 
  5. ^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  6. ^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura

Spoljašnje veze

CBiPES на Викимедијиној остави.

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