AMN082

AMN082
Nazivi
IUPAC naziv
N,N'-dibenzhidriletan-1,2-diamin dihidrohlorid
Identifikacija
3D model (Jmol)
ChemSpider
  • C(NCCNC(c1ccccc1)c2ccccc2)(c3ccccc3)c4ccccc4.Cl.Cl
  • Cl.Cl.N(CCNC(c1ccccc1)c2ccccc2)C(c3ccccc3)c4ccccc4
Svojstva
C28H30Cl2N2
Molarna masa 465,4572
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
Зелена квачицаДа verifikuj (šta je Зелена квачицаДаRed КрстићНе ?)
Reference infokutije

AMN082 (N,N'-dibenzhidriletan-1,2-diamin dihidrohlorid) je selektivni alosterni agonist metabotropnog glutamatnog receptora 7 (mGluR7).[3][4] On oponaša dejstvo glutamata. AMN082 je prvi selektivni mGluR7 agonist.

Reference

  1. ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  уреди
  2. ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1. 
  3. ^ Li X, Gardner EL, Xi ZX (2008). „The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate, but not dopamine, in rats”. Neuropharmacology. 54 (3): 542—51. PMC 2410088 Слободан приступ. PMID 18155073. doi:10.1016/j.neuropharm.2007.11.005. 
  4. ^ Palucha A, Klak K, Branski P, van der Putten H, Flor PJ, Pilc A (2007). „Activation of the mGlu7 receptor elicits antidepressant-like effects in mice”. Psychopharmacology (Berl.). 194 (4): 555—62. PMID 17622518. doi:10.1007/s00213-007-0856-2. 

Spoljašnje veze

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.