ACPD

ACPD
Stereo, skeletal formula of ACPD ((1S,3S)-1-amino,-1,3-dicarboxylic acid)
Nazivi
Sistemski IUPAC naziv
1-Aminociklopentan-1,3-dikarboksilna kiselina[1]
Identifikacija
3D model (Jmol)
Abrevijacija ACPD
ChemSpider
MeSH 1-amino-1,3-dicarboxycyclopentane
RTECS GY4060000 (1S,3R)
  • NC1(CCC(C1)C(O)=O)C(O)=O
Svojstva
C7H11NO4
Molarna masa 173,17 g·mol−1
Agregatno stanje Beli kristali
20 g dm-3
Rastvorljivost u etanol 240 mg dm-3
log P -0,709
Kiselost (pKa) 2,112
Baznost (pKb) 11,885
Izoelektrična tačka 2,84
Opasnosti
GHS grafikoni The exclamation-mark pictogram in the Globally Harmonized System of Classification and Labelling of Chemicals (GHS)
GHS signalna reč Warning
H302, H312, H315, H319, H332, H335
P261, P280, P305+351+338
Harmful Xn
R-oznake R20/21/22, R36/37/38
S-oznake S26, S36/37
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
Зелена квачицаДа verifikuj (šta je Зелена квачицаДаRed КрстићНе ?)
Reference infokutije

1-Amino-1,3-dikarboksiciklopentan (ACPD) je hemijsko jedinjenje koje se vezuje za metabotropni glutamatni receptor (mGluR).[4] ACPD deluje kao mGluR agonist. On je krut analog neurotransmitera glutamata koji ne aktivira jonotropne glutamatne receptore.[5] ACPD može da indukuje konvulzije kod neonatalnih pacova.[6]

Reference

  1. ^ „1-amino-1,3-dicarboxycyclopentane - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 25. 3. 2005. Identification and Related Records. Приступљено 15. 10. 2011. 
  2. ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.  уреди
  3. ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1. 
  4. ^ Schoepp DD, True RA (1992). „1S,3R-ACPD-sensitive (metabotropic) [3H]glutamate receptor binding in membranes”. Neurosci. Lett.. 145 (1): 100—4. PMID 1461560. doi:10.1016/0304-3940(92)90213-Q. 
  5. ^ Manzoni O, Fagni L, Pin JP, Rassendren F, Poulat F, Sladeczek F, Bockaert J (1990). „(trans)-1-amino-cyclopentyl-1,3-dicarboxylate stimulates quisqualate phosphoinositide-coupled receptors but not ionotropic glutamate receptors in striatal neurons and Xenopus oocytes”. Mol. Pharmacol.. 38 (1): 1—6. PMID 2164627. 
  6. ^ McDonald JW, Fix AS, Tizzano JP, Schoepp DD (1993). „Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist”. J. Neurosci.. 13 (10): 4445—55. PMID 8410197. 

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