PHCCC

PHCCC
Identifikatori
ATC kodnone
PubChemCID 3579925

PHCCC je istraživački lek koji deluje kao ligand glutamatnog receptora. On je pozitivni alosterni modulator mGluR4 podtipa,[1] kao i agonist mGluR6.[2] On ispoljava anksiolitičko dejstvo u životinjskim studijama.[3] PHCCC i slični lekovi su potencijalne nove terapije za Parkinsonovu bolest.[4]

Reference

  1. ^ Maj M, Bruno V, Dragic Z, Yamamoto R, Battaglia G, Inderbitzin W, Stoehr N, Stein T, Gasparini F, Vranesic I, Kuhn R, Nicoletti F, Flor PJ (2003). „(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection”. Neuropharmacology. 45 (7): 895—906. PMID 14573382. doi:10.1016/S0028-3908(03)00271-5. 
  2. ^ Beqollari D, Kammermeier PJ (2008). „The mGlu(4) receptor allosteric modulator N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide acts as a direct agonist at mGlu(6) receptors”. European Journal of Pharmacology. 589 (1–3): 49—52. PMID 18593581. doi:10.1016/j.ejphar.2008.06.054. 
  3. ^ Stachowicz K, Kłak K, Kłodzińska A, Chojnacka-Wojcik E, Pilc A (2004). „Anxiolytic-like effects of PHCCC, an allosteric modulator of mGlu4 receptors, in rats”. European Journal of Pharmacology. 498 (1–3): 153—6. PMID 15363989. doi:10.1016/j.ejphar.2004.07.001. 
  4. ^ Niswender CM, Johnson KA, Weaver CD, Jones CK, Xiang Z, Luo Q, Rodriguez AL, Marlo JE, de Paulis T, Thompson AD, Days EL, Nalywajko T, Austin CA, Williams MB, Ayala JE, Williams R, Lindsley CW, Conn PJ (2008). „Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4”. Molecular Pharmacology. 74 (5): 1345—58. PMC 2574552 Слободан приступ. PMID 18664603. doi:10.1124/mol.108.049551. 

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