L-AP4

L-AP4
Identifikatori
CAS broj23052-81-5 Зелена квачицаДа
ATC kodnone
PubChemCID 179394
IUPHAR/BPS1412

L-AP4 je lek koji se koristi u naučnim istraživanjima. On deluje kao agonist koji je selektivan za grupu III metabotropnih glutamatnih receptora (mGluR4/6/7/8). On je bio privi ligand za koji je utvrđeno da deluje kao selektivni agonist za ovu grupu mGlu receptora.[1] On se koristi u izučavanju ove receptorske familije i njihovih funkcija.[2][3][4][5]

Reference

  1. ^ Thomsen C (1997). „The L-AP4 receptor”. General pharmacology. 29 (2): 151—8. PMID 9251893. 
  2. ^ Lopez S, Turle-Lorenzo N, Acher F, De Leonibus E, Mele A, Amalric M (2007). „Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson's disease”. Journal of Neuroscience. 27 (25): 6701—11. PMID 17581957. doi:10.1523/JNEUROSCI.0299-07.2007. 
  3. ^ MacInnes N, Duty S (2008). „Group III metabotropic glutamate receptors act as hetero-receptors modulating evoked GABA release in the globus pallidus in vivo”. European journal of pharmacology. 580 (1–2): 95—9. PMID 18035348. doi:10.1016/j.ejphar.2007.10.030. 
  4. ^ Zhang HM, Chen SR, Pan HL (2009). „Effects of Activation of Group III Metabotropic Glutamate Receptors on Spinal Synaptic Transmission in a Rat Model of Neuropathic Pain”. Neuroscience. 158 (2): 875—84. PMC 2649787 Слободан приступ. PMID 19017536. doi:10.1016/j.neuroscience.2008.10.042. 
  5. ^ MacIejak P, Szyndler J, Turzyńska D, Sobolewska A, Taracha E, Skórzewska A, Lehner M, Bidziński A, Hamed A (2009). „The effects of group III mGluR ligands on pentylenetetrazol-induced kindling of seizures and hippocampal amino acids concentration”. Brain research. 1282: 20—7. PMID 19481536. doi:10.1016/j.brainres.2009.05.049. 

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