MTEP

MTEP
Identifikatori
CAS broj329205-68-7 Зелена квачицаДа
ATC kodnone
PubChemCID 9794218

3-[(2-Metil-4-tiazolil)etinil]piridin (MTEP) je lek koji se koristi u naučnim istraživanjima. Razvila ga je kompanija Merck & Co.. On je selektivan alosteran antagonist metabotropnog glutamatnog receptora mGluR5. On je identifikovan putem studija odnosa strukture i aktivnosti starijeg mGluR5 antagonista MPEP.[1] MTEP je naknadno korišten kao vodeće jedinjenje za novije i potentnije lekiva.[2][3]

Reference

  1. ^ Cosford ND; Tehrani L; Roppe J; et al. (2003). „3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity”. J. Med. Chem.. 46 (2): 204—6. PMID 12519057. doi:10.1021/jm025570j. 
  2. ^ Iso Y; Grajkowska E; Wroblewski JT; et al. (2006). „Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications”. J. Med. Chem.. 49 (3): 1080—100. PMID 16451073. doi:10.1021/jm050570f. 
  3. ^ Kulkarni SS, Newman AH (2007). „Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists”. Bioorg. Med. Chem. Lett.. 17 (11): 2987—91. PMC 1973162 Слободан приступ. PMID 17446071. doi:10.1016/j.bmcl.2007.03.066. 

Spoljašnje veze

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.