CDPPB

CDPPB
Identifikatori
CAS broj781652-57-1 Зелена квачицаДа
ATC kodnone
PubChemCID 11245456
IUPHAR/BPS1422

CDPPB je lek koji se koristi u naučnim istraživanjima. On deluje kao pozitivni alosterni modulator koji je selektivan za metabotropni glutamatni receptor mGluR5.[1][2][3] On ima antipsihotičke efekte u životinjskim modelima.[4] and mGluR5 Modulatori se istražuju kao potencijalni lekovi za tretman šizofrenije,[5] i drugih bolesti.[6][7]

Reference

  1. ^ Lindsley CW, Wisnoski DD, Leister WH, O'brien JA, Lemaire W, Williams DL, Burno M, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Duggan ME, Hartman GD, Conn PJ, Huff JR (2004). „Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo”. Journal of Medicinal Chemistry. 47 (24): 5825—8. PMID 15537338. doi:10.1021/jm049400d. 
  2. ^ de Paulis T, Hemstapat K, Chen Y, Zhang Y, Saleh S, Alagille D, Baldwin RM, Tamagnan GD, Conn PJ (2006). „Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes”. Journal of Medicinal Chemistry. 49 (11): 3332—44. PMID 16722652. doi:10.1021/jm051252j. 
  3. ^ Chen Y, Nong Y, Goudet C, Hemstapat K, de Paulis T, Pin JP, Conn PJ (2007). „Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses”. Molecular Pharmacology. 71 (5): 1389—98. PMID 17303702. doi:10.1124/mol.106.032425. 
  4. ^ Kinney GG, O'Brien JA, Lemaire W, Burno M, Bickel DJ, Clements MK, Chen TB, Wisnoski DD, Lindsley CW, Tiller PR, Smith S, Jacobson MA, Sur C, Duggan ME, Pettibone DJ, Conn PJ, Williams DL (2005). „A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models”. The Journal of Pharmacology and Experimental Therapeutics. 313 (1): 199—206. PMID 15608073. doi:10.1124/jpet.104.079244. 
  5. ^ Lindsley CW, Shipe WD, Wolkenberg SE, Theberge CR, Williams DL, Sur C, Kinney GG (2006). „Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia”. Current Topics in Medicinal Chemistry. 6 (8): 771—85. PMID 16719816. doi:10.2174/156802606777057599. 
  6. ^ Lecourtier L, Homayoun H, Tamagnan G, Moghaddam B (2007). „Positive allosteric modulation of metabotropic glutamate 5 (mGlu5) receptors reverses N-Methyl-D-aspartate antagonist-induced alteration of neuronal firing in prefrontal cortex”. Biological Psychiatry. 62 (7): 739—46. PMC 2910402 Слободан приступ. PMID 17511968. doi:10.1016/j.biopsych.2006.12.003. 
  7. ^ Gass JT, Olive MF (2009). „Positive allosteric modulation of mGluR5 receptors facilitates extinction of a cocaine contextual memory”. Biological Psychiatry. 65 (8): 717—20. PMC 2870714 Слободан приступ. PMID 19100966. doi:10.1016/j.biopsych.2008.11.001. 

Spoljašnje veze

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.