CCL1

Hemokin (C-C motiv) ligand 1
Identifikatori
SimbolCCL1
Alt. simboliSCYA1, I-309, TCA3, P500, SISe
Entrez6346
HUGO10609
OMIM182281
PDB1EL0
RefSeqNM_002981
UniProtP22362
Ostali podaci
LokusHromozom 17 q11.2

CCL, hemokin (C-C motiv) ligand 1, je mali glikoprotein koji izlučuju aktivirane T ćelije iz familije inflamatornih citokina poznatih kao hemokini.[1] CCL1 privlači monocite, NK ćelije, nezrele B ćelije i dendritske ćelije putem interakcije sa hemokin receptorom na površini ćelijske membrane koji se naziva CCR8.[2] Gen ovog hemokina počiva u velikom klasteru CC hemokina na ljudskom hromozomu 17.[3]

Reference

  1. ^ Miller MD, Krangel MS (1992). „The human cytokine I-309 is a monocyte chemoattractant”. Proc. Natl. Acad. Sci. U.S.A.. 89 (7): 2950—4. PMC 48781 Слободан приступ. PMID 1557400. 
  2. ^ Roos RS, Loetscher M, Legler DF, Clark-Lewis I, Baggiolini M, Moser B (1997). „Identification of CCR8, the receptor for the human CC chemokine I-309”. J. Biol. Chem.. 272 (28): 17251—4. PMID 9211859. 
  3. ^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 

Literatura

Spoljašnje veze

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