CXCL2

Hemokin (C-X-C motiv) ligand 2
Identifikatori
SimbolCXCL2
Alt. simboliSCYB2, GRO2, GROb, MIP-2a, MGSA-b, CINC-2a
Entrez2920
HUGO4603
OMIM139110
RefSeqNM_002089
UniProtP19875
Ostali podaci
LokusHromozom 4 q21

CXCL2, hemokin (C-X-C motiv) ligand 2, je mali citokin koji pripada CXC hemokin familiji. Os se takođe zove makrofagni inflamatorni protein 2-alfa (MIP2-alfa), rast-regulisani protein beta (Gro-beta) i Gro onkogen-2 (Gro-2). CXCL2 is 90% identičan u aminokiselinskoj sekvenci sa hemokinom, CXCL1. Ovaj hemokin izlučuju monociti i makrofage i on izaziva hemotaksu polimorfonuclearnih leukocita i hematopoetskih stem ćelija.[1][2][3] Gen za CXCL2 je lociran na ljudskom hromozomu 4 u klasteru sa drugim CXC hemokinima.[4] CXCL2 mobiliše ćelije putem interakcije sa hemokin receptorom na ćelijskoj površini koji se zove CXCR2.[3][5]

Reference

  1. ^ Wolpe, S. D., Sherry, B., Juers, D., Davatelis, G., Yurt, R. W., Anthony Cerami (1989). „Identification and characterization of macrophage inflammatory protein 2.”. Proc. Nat. Acad. Sci.. 86: 612—616. PMID 2643119. 
  2. ^ Iida N.; Grotendorst G.R. (1990). „Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue”. Mol. Cell. Biol.. 10: 5596—5599. PMID 2078213. 
  3. ^ а б Pelus LM, Fukuda S (2006). „Exp Hematol”. 34 (8): 1010—20. PMID 16863907. 
  4. ^ O'Donovan, N., Galvin, M., Morgan, J. G. (1999). „Physical mapping of the CXC chemokine locus on human chromosome 4”. Cytogenet. Cell Genet.. 84: 39—42. PMID 10343098. 
  5. ^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 

Literatura

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