CCL8

Hemokin (C-C motif) ligand 8
Identifikatori
SimbolCCL8
Alt. simboliSCYA8, MCP-2, HC14
Entrez6355
HUGO10635
OMIM602283
RefSeqNM_005623
UniProtP80075
Ostali podaci
LokusHromozom 17 q11.2

CCL8, hemokine (C-C motiv) ligand 8, je mali citokin iz CC hemokin familije koji se nekad zvao monocit hemotaksni protein-2 (MCP-2). CCL8 protein nastaje iz prekurzora koji sadrži 109 aminokiselina, koji se preseca da bi nastao CCL8 sa 75 aminokiseline. Gen za CCL8 је kodiran sa 3 eksona i lociran je unutar velikog klastera CC hemokina na hromozomu 17 q11.2 kod ljudi.[1][2] MCP-2 je hemoatraktant i activira mnoge vrste imunskih ćelija, uključujući mast ćelije, eozinofile i bazofile, (koji su implicirani u alergijske response), i monocite, T ćelije, i NK ćelije koje učestvuju u inflamatorni respons.[3][4] CCL8 dejstvuje putem vezivanja za nekoliko različitih hemokin receptora na ćelijskoj površini. U toj grupi receptora su CCR1, CCR2B i CCR5.[4][5]

Reference

  1. ^ Van Coillie,; et al. (1997). „The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2.”. Genomics. 40: 323—331. 
  2. ^ Van Damme; et al. (1992). „Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family.”. J. Exp. Med.. 176: 59—65. 
  3. ^ Proost; et al. (1996). „Human monocyte chemotactic proteins-2 and -3: structural and functional comparison with MCP-1.”. J Leukoc Biol. 59: 67—74. 
  4. ^ а б Gong; et al. (1998). „Monocyte Chemotactic Protein-2 Activates CCR5 and Blocks CD4/CCR5-mediated HIV-1 Entry/Replication”. J Biol Chem. 273: 4289—4292. 
  5. ^ Mire-Sluis, Anthony R.; Thorpe, Robin, ур. (1998). Cytokines (Handbook of Immunopharmacology). Boston: Academic Press. ISBN 0-12-498340-5. 

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